platelet disorders

Question 1

What are the two major problems causing platelet disorder?

Answer 1

1. Reduced platelet production
2. Increases platelet destruction
3. Sequesteration
4. Diltution

Question 2

Name 4 categories causing reduced platelet production?

Answer 2

1. bone marrow failure
2. bone marrow infiltration
3. improved production of platelets
4. nutritional deficiency

Question 3

what is the consequence of bone marrow failure?

Answer 3

aplastic anaemia

Question 4

Name 3 consequences of one marrow infiltration?

Answer 4

1 . leukaemia

2. lymphoma
3. multiple myeloma

Question 5

Name 1 consequences of nutritional deficiency?

Answer 5

1. B12/folate deficiency

2. megaloblastic anaemia

Question 6

Name 3 causes of increased platelet destruction?

Answer 6

1. acute immune thrombocytopenic purpura
2. drugs - quinine, rifampicin
3. DIC / haemolytic uraemic syndrome

Question 7

Name 1 cause of Sequesteration?

Answer 7

hypersplenism - large spleen causes excess platelet destruction