Side effects Flashcards
CV: cutaneous flushing
vancomycin
niacin (B3)
adenosine
dihydropyridine CCB
CV: vasospasm
cocaine amphetamines methamphetamines -triptans ergotamines
CV: Dilated cardiomyopathy
dexorubicin
donorubicin
cardiotoxicity and bone marrow suppression because these are anti- cancer drugs
CV: Torsades de pointes
Tx: MgSO4
QT interval prolongation:
Class 3 antiarrhythmics which are potassium channel blockers
Class 1a antiarrythmics, which are sodium channel blockers (macrolides, haloperidol, chloroquine, protease inhibitors)
Hematology: thrombocytopenia
heparin
cimetadine (H2 blocker)
Hematology: Agranulocytosis
Clozapine Carbamazepine Colchicine PTU Methimazole Dapsone
Hematology: aplastic anemia
Chloramphenicol Benzene NSAIDs PTU Methimazole
Hematology: Gray baby syndrome
Chloramphenicol (UDP glucoronyl- transferase is underactive in babies)
Hematology: hemolysis in G6PD- deficient patients
isoniazid sulfonamides primaquine high- dose aspirin ibuprofen nitrofurantoin dapsone fava beans naphthalene
Hematology: thrombosis
OCPs, especially in a smoker older than 35 years
Respiratory: pulmonary fibrosis
amiodarone
bleomycin
busulfan
Respiratory: cough
ACEI
a tickly cough mediated by bradykinin
GI: pseudomembranous colitis
clindamycin
amoxicillin/ ampicillin
GI: focal to massive hepatic necrosis
halothane
acetaminophen
valproic acid
amanita phalloides (mushroom toxin)
GI: hepatitis
INH
Endocrine: gynecomastia
Some drugs create awesome knockers:
spironolactone digoxin estrogen cimetadine chronic alcohol ketoconazole marijuana
Endocrine: adrenocortical insufficiency
withdrawal of corticosteroids
Endocrine: hot flashes
tamoxifen
clomiphene
Endocrine: Hypothyroidism
amiodarone (contains iodine)
lithium
sulfonamides
MSK: gout
furosemide thiazides niacin cyclosporin pyrazinamide
MSK: gingival hyperplasia
phenytoin
verapamil
MSK: osteoporosis
corticosteroids
heparin
MSK: photosensitivity
SAT (in the sun)
sulfonamides
amiodarone
tetracycline
MSK: SJS
seizure drugs: ethosuxamide carbamazepine lamotrigine phenytoin phenobarbitol
Sulfa drugs
Penicillin
Allopurinol
MSK: Drug induced lupus (check anti- histone ab)
SHIPP Sulfonamides Hydralazines Isoniazid Procainamide Phenytoin
MSK: tendon rupture/ cartilage damage
Fluoroquinolones
Renal: Interstitial nephritis
NSAIDs
furosemide
antibiotics
Renal: DI
note: treat renal DI with HCTZ (improper kidney response to ADH)
Lithium
Demeclocycline
Renal: Fanconi proximal tubule defect where protein is spilled
Expired tetracycline
Heavy metal exposure
Hemorrhagic cystitis
Cyclophosphamide
Ifosfamide
Neuro: Parkinson- like
Metoclopramide
Antipsychotics
Reserpine
Neuro: cinchonism (dizziness with HA, vision changes, tinnitus)
Quinidine
Quinine
Neuro: seizures
Buproprion Imipenem/cilastin INH Tramadol Metoclopramide Benzodiazepine/alcohol withdrawal
Neuro: Tardive dyskinesia
Antipsychotics
Multiorgan: Disulfiram- like reaction
Metronidazole Certain Cephalosporins Procarbazine First gen sulfonylureas Disulfiram
Nephrotoxicity and neurotoxicity
Aminoglycosides
Cisplatin
Polymixin
Nephrotoxicity and ototoxicity
Aminoglycosides
Vancomycin
Loop diuretics
Cisplatin
Anticholinergic effects Dry as a bone Hot as a hare Red as a beet Blind as a bat Mad as a hatter Bloated as a toad
Atropine TCAs H1 Blockers Thioridizine Chlorpromazine
avoid in patients with delirium, dementia, BPH pts
Lithium
LMNOP
Lithium side effects:
Movement (Tremor)
Nephrogenic DI because Lithium blocks ADH
Hypothyroidism
Pregnancy problems (teratogenic- Ebstein anomaly and malformation of the great vessels)
