Sickle cell disease Flashcards
1
Q
how would you manage a sickle cell crisis?
A
oxygen hydration (IV fluids) analgesia (NSAIDS, opiates) consider antibiotics blood transfusion exchange transfusion if neurological complications
2
Q
what prophylaxis is given for sickle cell crises?
A
vaccine - pneumococcal every 5yrs
penicillin
folic acid
3
Q
at what P02 does homozygotes and heterozygotes experience symptoms?
A
homozygotes sickle at P02 2.5-4 kPa
heterozygotes sickle at P02 5-6 kPa
4
Q
how does hydroxycarbamide work?
A
switches on gamma chains to produce foetal haemoglobin (HgF)
5
Q
what investigation is carried out to diagnose sickle cell anaemia?
A
haemoglobin electrophoresis