Lymphoma Flashcards

1
Q

what is the treatment regime for diffuse large B-cell lymphoma?

A

RCHOP

R: rituximab 
C: cyclophosphamide 
H: hydroxydaunomycin / daunorubicin 
O: oncovin / vincritine 
P prednisolone
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2
Q

what mutation is associated with burkitts lymphoma?

A

c-myc gene translocation , usually t(8:14)

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3
Q

what is characteristic of burkitts lymphoma on microscopy?

A

starry sky appearance

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4
Q

what is a complication of treatment for burkits lymphoma and how is this prevented?

A

tumour lysis syndrome due to rapid response to chemotherapy
give rasburicase before starting chemotherapy

rasburicase is a recombinant form of urate oxidase, an enzyme which catalyses the conversion uric acid to allopurinol (allantoin is more water soluble than uric acid so renal excretion is better)

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5
Q

what are features on presentation which distinguish hodgkins from non-hodgkins lymphoma?

A

hodkins lymphoma can have alcohol induced pain at lymph node
B symptoms occur earlier in hodgkins compared to non-hodgkins
extra-nodal disease much more common in non-hodgkins

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6
Q

how is lymphoma staged?

A

Ann Arbor staging

I: single lymph node above diaphragm
II: 2 or more lymph nodes above diaphragm
III: lymph nodes on both sides of diaphragm
IV: + anaemia / ITP

A: no systemic symptoms
B: fever > 38, weight loss > 10% in past 6 months, night sweats

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7
Q

what are poor prognostic indicators for non-hodgkins lymphoma?

A
B symptoms
stage IV 
age > 45yrs 
male 
albumin < 40g/l
WBC > 15000 /ul 
lymphocyte count < 600 or < 8%
haemoglobin < 10.5
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8
Q

what type of anaemia is found in hodgkins lymphoma?

A

normocytic anaemia

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9
Q

Reed sternberg cells are associated with what type of lymphoma?

A

hogdkins lymphoma

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10
Q

‘stary sky’ appearance is associated with what type of lymphoma?

A

burkitts lymphoma

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11
Q

what are the histological classifications of hodgkins lymphoma?

A

nodular sclerosing - more common in women, african subtyp
mixed cellularity - associated with large number of reed-sternberg cells
lymphocyte predominant - best prognosis
lymphocyte deplete - worst prognosis

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