Hyposplenism / splenomegaly Flashcards
1
Q
what are causes of hyposplenism?
A
splenectomy coeliac disease sickle cell disease SLE sarcoidosis graves disease
2
Q
what are causes of a massive splenomegaly?
A
myelofibrosis chronic myeloid leukaemia visceral leishmaniasis malaria Gaucher's disease
3
Q
what are functions of the spleen?
A
filtration of blood removes old/damaged RBC controls levels of cells synthesises immunoglobulins removes microorganisms from circulation
4
Q
where does the spleen lie?
A
between 7th - 10th ribs
5
Q
what histological features are found in hyposplenism?
A
Howell-Jolly bodies
siderocytes
