Shock part 5

Question 1

SUDAFED PE has no effect on nasal decongestion

Question 2

Phenyelephrine acts on alpha 1 selective and causes vasoconstriction

Question 3

Alpha 1 Gq which activates IP3 and triggers release of stored calcium bind with calmodulin and activates MLC kinase and causes phosphorylation of mysoin light chain and promotes actin-myosin cross-bridge formation and causes contraction and increases vascular smooth cells

Question 4

______________:B1 agonist
Synthetic analog of dopamine
but NO effect on dopamine receptors

binds to b1 which increases cardiac output and increase blood pressure

downside of increasing cardiac output since your increasing oxygen demand but pt is having problem with delivering oxygen tissues which is increasing oxygen demand of the heart, you can increase the risk of cardiac ischemia so don’t want to use this long term

Answer 4

Dobutamine

Question 5

Dobutamine is the inotropic agent of choice when increased cardiac output is needed

Question 6

________________:inotrope+vasodilator (inodilator) increases cAMP, PDE inhibitor

Answer 6

milrinone

Question 7

PDE-3 breaks cAMP

Question 8

What does PDE-5 break down? cyclic GMP

Question 9

Inhibition of PDE-3–>1)

2)

cAMP increases contractility, so increases cardiac output

increase smooth muscle relaxation so increases vasodilation

Answer 9

inotropic

vasodilation

Question 10

Vasopressin=ADH
secreted from pituitary gland
increases water absorption
V1 vascular
V2 renal
conserve water but also cause vasoconstriction so trying to raise blood pressure

Question 11

nitric oxide–>increase cGMP–>vasodilation

Question 12

Milrinone
Increase in _______ levels
Increase in K+ efflux–>__________

Answer 12

calcium

chyperpolarization