Part 1 Flashcards
Arterial thrombosis aka white thrombosis caused by ____flow, endothelial injury, and hypercoagulability
turbulent flow
Venous thrombosis aka red thrombosis caused by _______flow,and hyper coagulability
static
Venous thrombosis treated with _________
anticoagulants
Arterial thrombosis we treat with _________
antiplatelets
__________=Red thrombosis, low pressure, large veins, due to stasis, turbulence, high coagulability, composed mainly of fibrin and RBCs,loose: friable->embolus
venous thrombosis
white thrombosis, high pressure, in arteries(coronary arteries), due to endothelial injury/damage, composed of platelets, attached to arterial wall
arterial thrombosis
What conditions is antiplatelets used in?
ischemic stroke, heart attack (myocardial infarction)
Afib and DVT are treated with _____________
anticoagulants
Therapeutic uses for anti-platelet agents–>conditions associated with high risk of arterial thrombosis—>
acute coronary syndrome
ischemic stroke or _____
after stent replacement
After ________ surgery
_________(PAD)
TIA
After CABG
Peripheral artery disease
Don’t treat hemorraghic stroke pts with antiplatelets!!!!!!!!!! PT WILL DIE
Why is it important to have functional healthy endothelium
NO (nitric oxide)
Prostacyclin
Endogenous anti-coagulation mechanisms
which leads to ___________,anti-proliferative, anti-inflammatory, anti-thrombotic
vasodilatory
Endogenous anticoagulation produce by endothelium such as
Protein C/S, ___________
Protein C/S, and heparin
Endothelial injury/damage or dysfunction leads to vasoconstrictive, pro-atherogenic, pro-inflammatory, pro-thrombotic which leads to hypertension, atherosclerosis, and thrombosis
What can cause endothelial dysfunction?
HTN
__________(dyslipidemia)
___________ smoke–>toxins
________(hyperglycemia)
LDL-cholesterol
cigarette smoke
Diabetes
Increased endothelial injury and or dysfunction
increase atherosclerosis (ASCVD)
increase thrombosis
Tissue injury–>Platelet plug formation
Step 2–>coagulation fibrin mesh formatiion
