shigella vs salmonella

Question 1

morphologic difference btwn shigella and salmonella

Answer 1

salmonella = flagellate; shigella = no flagella

Question 2

virulence factors - shigella

Answer 2

produces shiga toxin (not main virulence factor); colonization and invasion of intestinal mucosa w/ PMN inflammation

Question 3

which ones invade the mucosa?

Answer 3

both! Salmonella triggers monocytic response; shigella triggers PMN infiltration

Question 4

effect of antibiotics on shigella? Salmonella?

Answer 4

salmonella = prolongs symptoms; shigella = shortens excretion in feces

Question 5

environmental reservoirs

Answer 5

salmonella = many animal reservoirs. Shigella = humans and primate sonly

Question 6

mechanism of dissemination - salmonella

Answer 6

hematogenous spread

Question 7

mechanism of dissemination - shigella

Answer 7

cell to cell transmission

Question 8

osteomyelitis and salmonella

Answer 8

most common cause of osteomyelitis in sickle cell anemia

Question 9

inoculum for shigella

Answer 9

only 10 cells needed for infection