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Step 1 > P450 interactions > Flashcards

P450 interactions Flashcards

1
Q

Acute alcohol abuse

A

inhibitor

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2
Q

amiodarone

A

inhibitor (k-channel blocker)

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3
Q

barbiturates

A

inducer (anxiety, seizures, insomnia, anethesia)

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4
Q

Carbamazepine

A

inducer (anti-convulsant, mood stabilizer)

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5
Q

Chronic alcohol use

A

inducer

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6
Q

Cimetidine

A

inhibitor (H2 antagonist)

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7
Q

Ciprofloxacin

A

inhibitor (fluoroquinolone - DNA gyrase inhibitor)

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8
Q

Gemfibrozil

A

inhibitor (fibrate, lowers triglycerides)

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9
Q

Grapefruit juice

A

inhibitor

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10
Q

Griseofulvin

A

inducer (superficial fungal infection - inhbits microtubule formation)

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11
Q

Isoniazid

A

inhibitior (decreases synthesis of mycolic acids

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12
Q

Ketoconazole (azole antifungals)

A

inhibitor (azole antifungal)

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13
Q

Macrolides (like erythromycin)

A

inhibitor (blcoks translocation of ribosomes)

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14
Q

modafinil

A

induce (daytime stimulant for narcolepsy)r

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15
Q

Phenytoin

A

inducer (anticonvulsant, Class IB antiarrhythmic)

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16
Q

Quinidine

A

inhibitior (antimalarial, Class IA antiarrhythmic)

17
Q

Rifampin

A

inducer (Hflu prophylaxis, Leprosy, TB - mRNA synthesis inhibitor)

18
Q

Ritonavir

A

Inhibitor (protease inhibitor)

19
Q

St. Jon’s Wort

A

inducer (Epinerphrine agonist

20
Q

Sulfonamides

A

inhibtor (PABA inhibitor, prevents DHF synthesis)

Step 1 (24 decks)

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