myasthenia gravis vs lambert eaton Flashcards
1
Q
etiologies of myasthenia gravis
A
autoantibodies vs POST synaptic Ach Receptor
2
Q
etiology of Lambert Eaton
A
Autoantibodies vs PREsynaptic Ca channel decreasing Ach release
3
Q
clinical presentation fo myasthenia gravis
A
ptosis, diplopia, weakness - worsening weakness with muscle use
4
Q
clinical presentation of lambert eaton
A
proximal muscle weakness (hip girdle weakness, can’t get out of chair), improves with muscle use (increased Ach released into synaptic cleft)
5
Q
Effect of AChE inhibitor on myasthenia
A
reversal of symptoms
6
Q
Effect of AChE inhibitor on lambert eaton
A
no effect
7
Q
therapy for myasthenia gravis
A
AChE inhibitor (pyridostygmine = long acting), immunosuppressants, thymectomy
