cytokines

Question 1

cytokines secreted by macrophages

Answer 1

IL1, IL6, IL8, IL12, TNFalpha

Question 2

cytokines secreted by all T-cells

Answer 2

IL2, IL3

Question 3

cytokines secreted by Th1 cells

Answer 3

IFN-y

Question 4

cytokines secreted by Th2 cells

Answer 4

IL4, IL5, IL10

Question 5

role of Th1 cells

Answer 5

promotes cytotoxic pathway. Antihumoral defense. Stimulates granulomas, macrophage activation, CD8 cell activation

Question 6

role of Th2 cells

Answer 6

promotes humoral immunity. Isotype switching.

Question 7

antiinflammatory cytokines

Answer 7

IL10, IL13, TGF-B

Question 8

IL1

Answer 8

pyrogen. Endothelium activation (LAD expression). Promotes differentiation of naive Th0 cells

Question 9

IL6

Answer 9

pyrogen.

Question 10

IL8

Answer 10

neutrophil chemotactic factor

Question 11

IL12

Answer 11

induces Th1 cell differentiation. Activates NK cells. Secreted by B cells

Question 12

TNFa

Answer 12

mediates septic shock = endothelium activation, vascular leakage, leukocyte recruitment.

Question 13

IL2

Answer 13

Autocrine signal for all T-cells to grow and differentiation. Paracrine signal for B-cell, mpnocytes and NK cells to grow.

Question 14

IL3

Answer 14

functiosn like GM-CSF - promotes bone marrow growth and differentiation

Question 15

IFN-g

Answer 15

activates macrophages and TH1. increases expression of MHC I and II in all cells.

Question 16

IL4

Answer 16

triggers Th2 cells to class switch to IgE and IgG

Question 17

IL5

Answer 17

triggers isotype switchign to IgA. Stimulates eosinophil growth and differentiation

Question 18

IL10

Answer 18

inhibits activation of T cells and Th1. Limits inflammatory cytokien production (TNFa, IL2, IL3, IFN-g)

Question 19

IFN-alpha and beta

Answer 19

secreted as paracrine signal in response to viral infection. Stimualtes cell to make antiviral proteins (inhibit viral protein synthesis, and degrade viral RNA)