Sexually Transmitted Diseases Flashcards
Which bacteria causes Chlamydia? State the serotypes that give clinical presentations of Chlamydia.
Chlamydia Trachomatis, serotypes D - K
What is the percentage of men and women who have asymptomatic Chlamydia?
50% men and 80% women
Which type of drug is Chlamydia not susceptible to?
beta-lactam antibiotics
Is the parasite causing Chlamydia enveloped or non-enveloped?
Enveloped
Treatment for Chlamydia
single dose of 1g of Azithromycin or Doxycycline 100mg twice daily for 7 days
Is the cell envelope of Chlamydia bacteria gram negative or gram positive?
Gram negative
What bacteria causes Gonorrhoea?
Neisseria Gonorrhoea
Describe the bacteria that causes Gonorrhoea.
Gram negative, aerobic cocci (diplococci)
Gonorrhoea is often co-infected with which 3 other conditions?
HIV, Chlamydia and genital warts
Percentage of men and women who are asymptomatic with Gonorrhoea
50% women
5% men
Treatment of uncomplicated Gonorrhoea
Ceftriaxone and azithromycin
What are the clinical manifestations of Gonorrhoea in males?
Gonococcal Urethritis (>80%) mucopurulent Dysuria (>50%) - pain in micturation Rectal infection (usually asymptomatic) can cause constipation, painful defecation and discharge Pharyngeal infection (usually asymptomatic)
What are the clinical manifestations of Gonorrhoea in females?
Endocervical infection (abnormal vaginal discharge) Pelvic inflammatory disease (only if endocervical infection isn't treated)
Which bacteria causes Syphilis?
Treponema Pallidum
What is the shape of Treponema Pallidum?
Spirochete
What are the clinical manifestations in secondary syphilis?
Maculopapular rash (raised rash) seen 6 weeks post primary lesion Condylomata lata in anogenital area (warts that are flattened,watery and very infective)
What are the clinical manifestations in tertiary syphilis?
Gummata (ulcerating lesions seen on skin and bones)
neuro-syphilis (dementia, Stroke, paralysis, blindness)
Cardiovascular syphilis (heart diseases)
What serotypes leads to anogenital warts?
Serotypes of Papillomavirus 6,11,16 and 18
What is caused by serotypes 1 and 4 of papillomavirus?
Plantar and facial warts
Which serotypes causes warts on knees and fingers?
Serotypes of papillomavirus 2,3, and 10
What causes Lymphogranuloma Venereum?
A type of Chlamydia bacteria that cause infection of mononuclear phagocytes in the lymphatic system.
(this is unlike genitourinary Chlamydia which infects squamocolumnar epithelial cells.)
What is the most sensitive test for detecting Chlamydia or Gonococcal infections?
NAAT testing
What treatment is recommended for Chlamydia?
Which is preferred if there are anorectal infections?
1G single dose of Azithromycin or Doxycycline 100MG BD PO for 7/7.
Doxycycline is preferred if patient has anorectal infections.
What are the complications of Chlamydia?
Pelvic Inflammatory Disease (PID) –> Can lead to Fitz-Hugh-Curtis Syndrome, a complication of PID
Infertility
Ectopic Pregnancy
Neonatal conjunctivitis or Neonatal pnuemonia/RDS
Reactive arthritis
What is the treatment for Gonorrhoea?
Single dose of Ceftriaxone 500MG IM + Single dose Azithromycin 1G PO
If IM is contraindicated, single dose Cefixime 400MG PO + Single dose Azithromycin 1G PO
If cephalosporins are contraindicated due to penicillin-allergy, Single dose Ciprofloxacin 500MG PO + Single dose Azithromycin 1G PO.
What is the mainstay of syphilis diagnosis?
Serology
What are the 2 types of serology testing for syphilis?
Non-treponemal serology and treponemal specific serology testings
What is detected for in Non-Treponemal serology testing?
In non-treponemal serology testing, detection of antibodies to non-specific antigens such as Cardiolipin which is present in most patients with Syphilis
What cream is prescribed for those with Genital Warts? What is the purpose served by the cream?
Imiquimod cream helps boost patient’s immune system to fight the genital warts
How is Lymphogranuloma Venereum different from Chlamydia infection?
Lymphogranuloma Venereum: Chlamydia Trachomatis Serotype L1, L2 and L3 causes infection of mononuclear phagocytes in the lymphatic system.
However, in genitourinary Chlamydia, bacteria Chlamydia Trachomatis infects the squamocolumnar epithelium.
What are buboes?
Buboes are grossly enlarged tender lymph nodes seen in patients with Lymphogranuloma Venereum.