Sex steroids

Question 1

Name some drugs that fit into the following categories:

• sex steroid hormone
• inhibitor / antagonist
• mixed agonist / antagonist

Answer 1

3

Question 2

How are sex steroids synthesised?

Answer 2

5,6

Question 3

Why is there a lag between giving a steroid hormone receptor antagonist and seeing an effect?

Answer 3

7

Question 4

Briefly describe affects of oestrogen, progesterone and testosterone

Answer 4

9-12

Question 5

How is oestrogen absorbed, metabolised and excreted

Answer 5

18

Question 6

How is progesterone absorbed, metabolised and excreted

Answer 6

19

Question 7

Which enzymes metabolise COCP /POP and how does this affect efficacy?

Answer 7

21

Question 8

How can HRT be administered?

Answer 8

25

Question 9

Risks of HRT?

Answer 9

28

Question 10

Role of bisphosphonates? When can they be used?

Answer 10

30

Question 11

Some ADRs of bisphophonates?

Answer 11

31

Question 12

What is mifepristone (RU486) used for, what is it’s outcome?

Answer 12

33

Question 13

What is clomiphene used for, what is it’s outcome?

Answer 13

36

Question 14

Give examples of SERMs

Answer 14

35

Question 15

How does tamoxifen work in endometrium / in breast?

Answer 15

37 - 38

Question 16

Fx of ulipristal acetate? How does it work?

Answer 16

39