8 NSAIDs Flashcards
1
Q
How are… synthesised?
- Arachidonic acid
- Prostanoids
A
4-7
2
Q
How does PGE2 affect gastric acid secretion
A
8
3
Q
How do prostanoids act?
A
Through many GPCRs
4
Q
Why is it important to balance PGI2 (prostacyclin) and TXA2 (thromboxane)?
A
10
5
Q
Where do COX-1 / 2 mostly act?
Name some homeostatic / pathological fx of each
A
12
6
Q
Explain how NSAIDs work as an analgesia
A
15
7
Q
Explain how NSAIDs work as an anti-inflammatory
A
16
8
Q
Explain how NSAIDs work as an antipyretic
A
17
9
Q
NSAIDs effect in GIT?
A
19
10
Q
NSAIDs effect renal?
A
20
11
Q
Why is COX-2 ‘better’ than COX-1?
A
22
12
Q
Paracetamol function?
A
27
13
Q
Sx of paracetamol overdose?
What to do?
A
29
14
Q
How is glutathione replenished?
A
31
