PK + PD

Question 1

What does a large Vd show?

Answer 1

Most of the drug is NOT in plasma

Mostly in intracellular space

Question 2

What is the calculation for Vd?

Answer 2

Dose / (drug) plasma

Question 3

What are the 2 phases in metabolism of drugs?

Answer 3

18

Question 4

What effects can CYPs have on drugs?

Answer 4

20

Question 5

What factors can affect phase 1 metabolism?

Answer 5

20

Question 6

Explain the metabolism of carbamazepine

Answer 6

22

Question 7

What factors affect renal clearance?

Answer 7

24

Question 8

What is enterohepatic circulation

Answer 8

The enterohepatic circulation (EHC) of drugs is the excretion of the metabolite into bile, followed by reabsorption of drug into the systemic circulation.

Question 9

What needs to be considered in hepatic clearance?

Answer 9

25

Question 10

How can ABx affect drug metabolism?

Answer 10

Disrupt normal drug flora

Question 11

How is half life affected by concentration?

Answer 11

Independent of conc

Question 12

Define clearance

Give units and calculation

Answer 12

30

Question 13

Explain the relationship between elimination rate and Vd

Answer 13

31

Question 14

Give the equation for half life

Answer 14

31

Question 15

How many half lifes for plasma to reach a steady state (Css)?
What is Css?

Answer 15

35

Question 16

What is the calculation for maintenance dose?

Answer 16

40

Question 17

What is the benefit of loading doses?

Answer 17

41

Question 18

Give calculation for loading doses

Answer 18

41

Question 19

Define terms on page 45

Answer 19

46