9 Opioids Flashcards
1
Q
Compare nociception with pain
A
3
2
Q
Describe pathway of pain
A
4
3
Q
How is pain modulated centrally / peripherally?
A
6
4
Q
How is pain reduced peripherally?
A
8
5
Q
How is pain reduced centrally?
A
10
6
Q
Name 3 endogenous opioids and 3 R subtypes
What are opioid R/
A
12
GPCR
7
Q
Where is MOP R found and what is it’s Fx?
A
13
8
Q
How does opioid uncoupling decrease pain?
A
15
9
Q
What is the effect of arrestin on increasing pain?
Explain the mechanism
A
16
10
Q
What is the effect of suddenly removing an opioid?
A
18
11
Q
Explain the absorbtion, distribution, metabolsim, elimination of morphine
A
25
12
Q
MoA / action / side effects morphine
A
26
13
Q
Explain the absorbtion, distribution, metabolsim, elimination of fentanyl
A
27
14
Q
MoA / action / side effects fentanyl
A
28
15
Q
Explain the absorbtion, metabolsim, elimination of codine
A
29
