9 Opioids Flashcards
Compare nociception with pain
3
Describe pathway of pain
4
How is pain modulated centrally / peripherally?
6
How is pain reduced peripherally?
8
How is pain reduced centrally?
10
Name 3 endogenous opioids and 3 R subtypes
What are opioid R/
12
GPCR
Where is MOP R found and what is it’s Fx?
13
How does opioid uncoupling decrease pain?
15
What is the effect of arrestin on increasing pain?
Explain the mechanism
16
What is the effect of suddenly removing an opioid?
18
Explain the absorbtion, distribution, metabolsim, elimination of morphine
25
MoA / action / side effects morphine
26
Explain the absorbtion, distribution, metabolsim, elimination of fentanyl
27
MoA / action / side effects fentanyl
28
Explain the absorbtion, metabolsim, elimination of codine
29
Explain the absorbtion, distribution, metabolsim, elimination of buprenorphine
31
MoA / action / side effects buprenorphine
32
Explain the absorbtion, distribution, metabolsim, elimination of naloxone
33
MoA / action / side effects naloxone
34
Most common cx of death in opioid overdose
36
Considerations when prescribing opioids
37
Opioid dose for pallative care
- months to weeks
- days to hours
40
