8 immunosupression Flashcards

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1
Q

Rheumatoid arthritis pathogenisis

A

5

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2
Q

Criteria for RA (clinical and non-clinical)

A

6

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3
Q

RA Tx

A

8

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4
Q

What is SLE and vascularitis?

A

SLE- An autoimmune disease, with systemic manifestations including skin rash, erosion of joints or even kidney failure.
V- A group of conditions characterised by the inflammation of blood vessels. This causes headache, fatigue and fever.

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5
Q

Tx for SLE and vascularitis

A

12

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6
Q

MoA of corticosteroids

A

13

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7
Q

Maintenance for SLE and vasculitis

A

azothioprine

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8
Q

Azothioprine MoA

A

18, 19

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9
Q

Azothioprine adverse effects

A

20

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10
Q

Medication for atopic dermatitis + psoriasis

Drug catergory

A

21

calcineurin inhibitors

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11
Q

Name some CYP P450 inducers / inhibitors

A

22

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12
Q

Ciclosporin + tacrolimus MoA

A

23

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13
Q

Mycophenolate mofetil use

A

24

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14
Q

MoA mycophenolate mofetil

A

4 (.2)

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15
Q

Mycophenolate mofetil adverse effects

A

5 (8.2)

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16
Q

Function of cyclophosphamide

A

6 (8.2)

17
Q

MoA cyclophosphamide

A

7 (8.2)

18
Q

Cyclophosphamide risks

A

9 (8.2)

19
Q

Best tx for RA

A

11

20
Q

Methotrexate MoA

A

13

21
Q

Adverse effecfs methotrexate

A

17

22
Q

Effects of sulfasalazine on Tcells and neutrophils

What condition is it effective in?

A

20

IBD

23
Q

Sulfasalazine adverse effects

A

22

24
Q

What can be given in pregnancy and what must be avoided?

- sulfasalazine / metatrexate

A

23

25
Q

Effects of blocking TNF-alpha

What is the risk of this therapy

A

26

27

26
Q

Rituximab pathophysiology

In what conditions is it used?

A

29