8 immunosupression Flashcards
Rheumatoid arthritis pathogenisis
5
Criteria for RA (clinical and non-clinical)
6
RA Tx
8
What is SLE and vascularitis?
SLE- An autoimmune disease, with systemic manifestations including skin rash, erosion of joints or even kidney failure.
V- A group of conditions characterised by the inflammation of blood vessels. This causes headache, fatigue and fever.
Tx for SLE and vascularitis
12
MoA of corticosteroids
13
Maintenance for SLE and vasculitis
azothioprine
Azothioprine MoA
18, 19
Azothioprine adverse effects
20
Medication for atopic dermatitis + psoriasis
Drug catergory
21
calcineurin inhibitors
Name some CYP P450 inducers / inhibitors
22
Ciclosporin + tacrolimus MoA
23
Mycophenolate mofetil use
24
MoA mycophenolate mofetil
4 (.2)
Mycophenolate mofetil adverse effects
5 (8.2)
Function of cyclophosphamide
6 (8.2)
MoA cyclophosphamide
7 (8.2)
Cyclophosphamide risks
9 (8.2)
Best tx for RA
11
Methotrexate MoA
13
Adverse effecfs methotrexate
17
Effects of sulfasalazine on Tcells and neutrophils
What condition is it effective in?
20
IBD
Sulfasalazine adverse effects
22
What can be given in pregnancy and what must be avoided?
- sulfasalazine / metatrexate
23
Effects of blocking TNF-alpha
What is the risk of this therapy
26
27
Rituximab pathophysiology
In what conditions is it used?
29