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*MSK > Seronegative Arthritis > Flashcards

Seronegative Arthritis Flashcards

1
Q

What is seronegative arthritis?

A

Arthritis with negative rheumatoid factor

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2
Q

seronegative arthritis is associated with what?

A

HLA-B27
Asymmetric arthritis
Axial skeleton
Extra-articular features

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3
Q

What extra articular features is seronegative arthritis associated with?

A

Uveitis

Inflammatory bowel disease

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4
Q

What is the DDx of seronegative arthritis?

A

Ankylosing spondylitis
Psoriatic arthritis
Bowel-related arthritis
Reactive arthritis

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5
Q

What is Ankylosing Spondylitis?

A

Chronic inflammatory rheumatic disorder

Axial skeleton and entheses

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6
Q

When does Ankylosing Spondylitis onset?

A

Males ++

2nd/3rd decade

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7
Q

How is Ankylosing Spondylitis assessed?

A

Schober test
Spinal mobility (lateral spinal flexion)
Cervical rotation

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8
Q

What are the clinical features of Ankylosing Spondylitis?

A

Inflammatory back pain
Limited movements in antero-posterior/lateral lumbar planes
Limited chest expansion
Bilateral sacroiliitis on x-rays

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9
Q

How is Sacroiliitis graded radiographically?

A

Grade 0 - 4 (increasing abnormality)

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10
Q

How is Axial Spondyloarthritis diagnosed?

A

> 3mo back pain
Age <45
Sacroilitis on imaging OR HLA-B27+ve

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11
Q

HLA-B27 is associated with what conditions?

A

Ankylosing Spondylitis

Axial Spondyloarthritis

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12
Q

What are the features of Axial Spondyloarthritis?

A 
Inflammatory back pain
Arthritis 
Uveitis 
Dactylitis 
Psoriasis
Crohns 
Good response to NSAIDs
FH
HLA-B27
Raised CRP
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13
Q

How is Ankylosing Spondylitis managed?

A 
Physiotherapy
NSAIDs
DMARDs (sulfasalazine)
Anti-TNF
Anti-IL-17
Surgery (joint replacement)
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14
Q

Psoriatic Arthritis affects which joints?

A

Neck
All of arm/hand
Base of spine
All of leg/foot

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15
Q

Name 2 subtypes of Psoriatic Arthritis?

A

Arthritis with DIP involvement
Symmetric polyarthritis
Arthritis mutilans

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16
Q

How is Psoriatic Arthritis treated?

A 
Sulfasalazine
Methotrexate 
Leflunomide
Cyclosporine 
Anti-TNF/IL-17
Steroids
17
Q

What is reactive arthritis?

A

Sterile synovitis after distant infection

18
Q

Reactive arthritis is associated with which infections?

A 
Salmonella 
Shigella 
Yersina
Campylobacter
Chlamydia 
Trachomatis 
(throat, urogenital, GI)
19
Q

How does Reactive arthritis present?

A 
Mono/oligoarthritis 
May be systemic 
Post-infection
Dactylitis 
Enthesitis 
Urethritis
Conjunctivitis
20
Q

What are the prognostic signs of Chronic Reactive arthritis?

A

Hip/heel pain
High ESR
FH
HLA-B27+ve

21
Q

What is the treatment for acute Reactive arthritis?

A

NSAIDs
Joint injection
Antibiotics (chlamydia)

22
Q

What is the treatment for chronic Reactive arthritis?

A

NSAIDs

DMARDs

23
Q

What is Enteropathic Arthritis?

A

Arthritis associated with IBD, Infectious enteritis, Coeliac’s disease
Peripheral/axial disease

24
Q

How is Enteropathic Arthritis treated?

A

Sulfasalazine
Steroids
Methotrexate
Anti-TNF

*MSK (25 decks)

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