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*MSK > Auto-immune mini-symposium > Flashcards

Auto-immune mini-symposium Flashcards

1
Q

How are multi-system autoimmune diseases diagnosed?

A 
Cardinal features (Hx, exam)
Immunology
Imaging
Tissue 
Exclusion
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2
Q

What is the classification criteria for SLE?

A 
4 of:
Malar rash
Discoid rash
Photosensitivity 
Oral ulcers 
Arthritis (2 joints)
Serositis 
Renal 
Neurological (seizures)
Haematological features
Immunological features
Anti-nuclear antibody
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3
Q

What are the skin manifestations of SLE?

A

Discoid/Malar rash

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4
Q

What is the presentation of Scleroderma?

A

Morphea
Hard, thickened areas of skin in different areas of the body
Limited or diffuse

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5
Q

What are the complications of limited scleroderma?

A

Pulmonary hypertension

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6
Q

What are the complications of diffuse scleroderma?

A

Pulmonary fibrosis
Renal crisis
Small bowel bacterial overgrowth

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7
Q

How does Sjogren’s syndrome present?

A

Dry eyes
Dry mouth
Parotid gland enlargement
Systemic upset (fatigue, fever, myalgia, arthralgia)

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8
Q

What are the complications of Sjogren’s syndrome?

A 
Lymphoma 
Neuropathy
Purpura 
Interstitial lung disease 
Renal tubular acidosis
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9
Q

How does Auto-immune myositis present?

A 
Symmetrical, diffuse, proximal Muscle weakness
Polymyositis
Dermatomyositis:
- Gottron's papules
- Heliotrope rash
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10
Q

What complications are associated with Auto-immune myositis?

A

Cancer

Interstitial lung disease

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11
Q

What are the large vessel vasculitidies?

A

Takayasu Arteritis

Giant Cell Arteritis

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12
Q

What are the medium vessel vasculitidies?

A

Polyarteritis Nodosa

Kawasaki disease

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13
Q

What are the small vessel vasculitidies?

A

ANCA-associated vasculitis

Immune Complex SVV

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14
Q

What are the diagnostic criteria for Giant Cell arteritis?

A 
3 of:
Age >50
New headache
STA tenderness
ESR >50
Abnormal temporal biopsy
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15
Q

What are the ANCA-associated vasculitidies

A

Granulomatosis with polyangiitis
Microscopic Polyangiitis
Eosiniphilic granulomatosis with polyangiitis

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16
Q

How does Granulomatosis with polyangiitis present?

A

Necrotising granulomatous inflammation (respiratory tract)
Nose bump
Necrotising glomerulonephritis

17
Q

How does Microscopic Polyangiitis present?

A

Necrotising vasculitis
Necrotising glomerulonephritis
Pulmonary capillaritis

18
Q

How does Eosiniphilic granulomatosis with polyangiitis present?

A

Respiratory tract inflammation with eosinophil-rich necrotising granulomatosis
Associated with asthma, eosinophilia

19
Q

What is the use of renal biopsy of Lupus?

A

Classification of lupus nephritis

1-6

20
Q

What is the treatment of multi-system autoimmune disease?

A 
Hydroxychloroquinine
Azathioprine
Methotrexate 
Cyclophosphamide
Rituximab

*MSK (25 decks)

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