Second Half I F24: Lecture Slides 20 - 33 Flashcards
What is Phosphoric Acid (H3PO4?)
Triprotic Acid
What happens at neutral pH to Phosphoric Acid?
It exists as an equilibrium mixture of H2PO4- and HPO42-
What is this equilibrium mixture repented by?
Pi (inorganic phosphate)
What does phosphorylation add?
Negative charge to molecules, leading to an increase in water solubility (phospholipids, DNA, RNA, many proteins)
When Phosphoric Acid reacts with Alcohols, what does it produce?
Phosphate Ester
When Phosphoric Acid rects with an acid what is produced?
Phosphoanhydride
What are phosphoglycerides (Glycerophospholipids)?
Primary constituent of biological membranes
What happens at Carbon Atoms Number 1 and 2 of glycerol?
They are esterfied to two fatty acids “tail” while a highly polar OR charged group X is attached through a phosp[hodietser linkage to the third “head
What are Glycerophospholipids considered?
Amphiphathic (combines both hydrophilic head and hydrophobic tail properties)
What is Phosphatidylcholine?
Represents a class of lipid rather than a single molecule
What do different combinations of fatty acids at positions R1 and R2 correspond to?
Different phosphatidylcholine molecules.
The complete hydrolysis or one mole of phosphatidylethanolamine yield the components glycerol, fatty acid, phosphate and ethanol amine in which molar ratios?
1:2:1:1
What do Fatty Acids Aggregate to form?
Roughly spherical Micelles
What happens to the hydrophobic tails of phospholipids?
They are too bulky to pack tightly together in micelles, so they aggregate into bilayers
What happens to bilayers?
They spontaneously fold back on themselves to form liposomes or vesicles as large as 1 micron
