Scott Van Zeeland

Question 1

What is the aim of Scott Van Zealand?

Answer 1

To identify genes
associated with
anorexia.

Question 2

Who were the ppts in Scott Van Zealand study?

Answer 2

• 262 females with AN
• 80 participants without AN (control)
• DNA samples taken from both
• Participants were matched on age and
ethnicity

Question 3

What was the research method inf Scott Van Zeelands study?

Answer 3

A genome wide
association study
(GWAS) that
identified genetic
markers that are
more frequent in
people with
anorexia.

Question 4

What was the procedure to Scott Van Zeelands study?

Answer 4

Participants’ DNA was compared
against 500 DNA samples from
individuals with AN and 500 DNA
samples from participants without AN.
• These samples were taken from the
Price Foundation Sample Repository.

Question 5

What were the results of Scott Can Zeelands study?

Answer 5

No single genetic variant is
associated with AN.
• However, a combination of
variants showed a
significant genetic
difference between the AN
participants and the
controls.
• Variants in the ITPR3 gene
and the EPHX2 gene could
be associated with the
disorder.

Question 6

What is a weakness of Scott Van Zeelands study?

Answer 6

Does not tell us how genes influence AN.

Question 7

What is a strength of Scott Van Zeelands study?

Answer 7

High in reliability. Procedures carried out consistently.