scleroderma Flashcards
1
Q
what does limited scleroderma spare?
A
kidneys
skin on trunk and proximal limbs
2
Q
typical group
A
women 30-50yrs
3
Q
underlying cause
A
increased collagen production in tissues
4
Q
antibodies
A
anti-centromere = limited scl-70 = systemic
5
Q
CREST
A
calcinosis raynauds esophageal dysmotility sclerodactyly telangiectasia
6
Q
first noticeable symptoms
A
skin on fingers become tight
fingers stiff and inflexible
raynauds - cold and blue
7
Q
later features
A
tightening skin around lips joint and muscle pain ulceration vascular disease pulmonary fibrosis PAH renal failure
8
Q
drugs to slow disease
A
cyclophosphamide
9
Q
management
A
physio, OT
analgesia, CCB, topical skin emollients, PPI and antacids
10
Q
treating pulmonary hypertension
A
bosentan
sildenafil
iloprost
11
Q
treating raynauds
A
nifedipine - CCB
12
Q
annual tests systemic sclerosis
A
echo and spirometry
13
Q
cure?
A
no
