ANCA associated vasculitis

Question 1

vasculitis affecting small vessels

Answer 1

Henoch-schonlein purpura
churg-strauss
microscopic polyangitis
granulomatosis with polyangitis - wegners

Question 2

vasculitis affecting medium vessels

Answer 2

polyarteritis nodosa
churg-strauss = eosoniphilic granulomatosis with polyangitis
kawasaki

Question 3

vasculitis affecting large vessels

Answer 3

GCA

Takayasu

Question 4

generic vasculitic symptoms

Answer 4

purpura
joint and muscle pain 
peripheral neuropathy 
renal impairment
GI disturbance 
anterior uveitis and scleritis 
hypertension

Question 5

systemic manifestations

Answer 5

fatigue
fever 
weight loss
anorexia 
anaemia

Question 6

blood test to remember

Answer 6

ANCA

Question 7

2 types of ANCA

Answer 7

c-ANCA and p-ANCA

Question 8

types of ANCA and what vasculitis associated with

Answer 8

p-ANCA = microscopic polyangitis and churg strauss
c-ANCA = wegners

Question 9

what markers are raised?

Answer 9

ESR and CRP

Question 10

main treatments

Answer 10

steroids and immunosuppressants

refer to rheumatology

Question 11

steroids

Answer 11

oral - prednisolone
IV = hydrocortisone
nasal sprays
inhaled - lung

Question 12

immunosuppressants

Answer 12

cyclophosphamide
MTX
azathioprine
rituximab

Question 13

what type of vasculitis is HSP?

Answer 13

IgA

Question 14

HSP presentation

Answer 14

purpuric rash of lower limbs and buttocks

Question 15

cause of HSP

Answer 15

IgA deposits in blood vessels of skin, kidneys and GI tract

Question 16

HSP trigger

Answer 16

upper airway infection eg tonsilitis or gastroenteritis

Question 17

HSP - who it affects

Answer 17

children under 10

Question 18

4 classic features of HSP

Answer 18

purpura
joint pain
abdominal pain
renal involvement

Question 19

what can HSP do to kidneys?

Answer 19

IgA nephritis

Question 20

treating HSP

Answer 20

supportive - hydration, analgesia

Question 21

What organs does eosonophilic granulomatosis with polyangitis affect?

Answer 21

lung and skin

Question 22

churg strauss presentation

Answer 22

severe asthma in late teens or adulthood

Question 23

churg strauss characteristic finding

Answer 23

elevated eosinophil

Question 24

features of microscopic polyangitis

Answer 24

renal failure

SOB and haemoptysis

Question 25

what does wegners affect?

Answer 25

respiratory tract and kidneys

Question 26

common finding of wegners

Answer 26

saddle shaped nose

Question 27

wegners symptoms

Answer 27

epistaxis and crusty nasal secretions sinusitis cough, wheeze, haemoptysis

Question 28

polyarteritis nodosa most associated with?

Answer 28

hepatitis B | hep C or HIV

Question 29

polyarteritis nodosa rash

Answer 29

livedo reticularis | mottled, purplish, lace like

Question 30

who does kawasaki disease affect?

Answer 30

children under 5

Question 31

clinical features of kawasaki

Answer 31

``` persistent high fever erythematous rash bilateral conjunctivitis erythema of palms and soles strawberry tongue ```

Question 32

key complication of kawasaki

Answer 32

coronary artery aneurysm

Question 33

treating kawasaki

Answer 33

aspirin and IvIg to avoid carotid aneurysm

Question 34

what vessel does takayasu's affect?

Answer 34

aorta | pulmonary arteries

Question 35

other name for takayasu's

Answer 35

pulseless disease

Question 36

presentation of takayasu's

Answer 36

under age of 40 fever, malaise, muscle aches arm claudication or syncope

Question 37

diagnosing takayasu's

Answer 37

CT or MRI angiography | doppler USS carotids