ANCA associated vasculitis Flashcards
vasculitis affecting small vessels
Henoch-schonlein purpura
churg-strauss
microscopic polyangitis
granulomatosis with polyangitis - wegners
vasculitis affecting medium vessels
polyarteritis nodosa
churg-strauss = eosoniphilic granulomatosis with polyangitis
kawasaki
vasculitis affecting large vessels
GCA
Takayasu
generic vasculitic symptoms
purpura joint and muscle pain peripheral neuropathy renal impairment GI disturbance anterior uveitis and scleritis hypertension
systemic manifestations
fatigue fever weight loss anorexia anaemia
blood test to remember
ANCA
2 types of ANCA
c-ANCA and p-ANCA
types of ANCA and what vasculitis associated with
p-ANCA = microscopic polyangitis and churg strauss c-ANCA = wegners
what markers are raised?
ESR and CRP
main treatments
steroids and immunosuppressants
refer to rheumatology
steroids
oral - prednisolone
IV = hydrocortisone
nasal sprays
inhaled - lung
immunosuppressants
cyclophosphamide
MTX
azathioprine
rituximab
what type of vasculitis is HSP?
IgA
HSP presentation
purpuric rash of lower limbs and buttocks
cause of HSP
IgA deposits in blood vessels of skin, kidneys and GI tract
HSP trigger
upper airway infection eg tonsilitis or gastroenteritis
HSP - who it affects
children under 10
4 classic features of HSP
purpura
joint pain
abdominal pain
renal involvement
what can HSP do to kidneys?
IgA nephritis
treating HSP
supportive - hydration, analgesia
What organs does eosonophilic granulomatosis with polyangitis affect?
lung and skin
churg strauss presentation
severe asthma in late teens or adulthood
churg strauss characteristic finding
elevated eosinophil
features of microscopic polyangitis
renal failure
SOB and haemoptysis
what does wegners affect?
respiratory tract and kidneys
common finding of wegners
saddle shaped nose
wegners symptoms
epistaxis and crusty nasal secretions
sinusitis
cough, wheeze, haemoptysis
polyarteritis nodosa most associated with?
hepatitis B
hep C or HIV
polyarteritis nodosa rash
livedo reticularis
mottled, purplish, lace like
who does kawasaki disease affect?
children under 5
clinical features of kawasaki
persistent high fever erythematous rash bilateral conjunctivitis erythema of palms and soles strawberry tongue
key complication of kawasaki
coronary artery aneurysm
treating kawasaki
aspirin and IvIg to avoid carotid aneurysm
what vessel does takayasu’s affect?
aorta
pulmonary arteries
other name for takayasu’s
pulseless disease
presentation of takayasu’s
under age of 40
fever, malaise, muscle aches
arm claudication or syncope
diagnosing takayasu’s
CT or MRI angiography
doppler USS carotids
