ANCA associated vasculitis Flashcards
vasculitis affecting small vessels
Henoch-schonlein purpura
churg-strauss
microscopic polyangitis
granulomatosis with polyangitis - wegners
vasculitis affecting medium vessels
polyarteritis nodosa
churg-strauss = eosoniphilic granulomatosis with polyangitis
kawasaki
vasculitis affecting large vessels
GCA
Takayasu
generic vasculitic symptoms
purpura joint and muscle pain peripheral neuropathy renal impairment GI disturbance anterior uveitis and scleritis hypertension
systemic manifestations
fatigue fever weight loss anorexia anaemia
blood test to remember
ANCA
2 types of ANCA
c-ANCA and p-ANCA
types of ANCA and what vasculitis associated with
p-ANCA = microscopic polyangitis and churg strauss c-ANCA = wegners
what markers are raised?
ESR and CRP
main treatments
steroids and immunosuppressants
refer to rheumatology
steroids
oral - prednisolone
IV = hydrocortisone
nasal sprays
inhaled - lung
immunosuppressants
cyclophosphamide
MTX
azathioprine
rituximab
what type of vasculitis is HSP?
IgA
HSP presentation
purpuric rash of lower limbs and buttocks
cause of HSP
IgA deposits in blood vessels of skin, kidneys and GI tract