ANCA associated vasculitis Flashcards

1
Q

vasculitis affecting small vessels

A

Henoch-schonlein purpura
churg-strauss
microscopic polyangitis
granulomatosis with polyangitis - wegners

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2
Q

vasculitis affecting medium vessels

A

polyarteritis nodosa
churg-strauss = eosoniphilic granulomatosis with polyangitis
kawasaki

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3
Q

vasculitis affecting large vessels

A

GCA

Takayasu

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4
Q

generic vasculitic symptoms

A
purpura
joint and muscle pain 
peripheral neuropathy 
renal impairment
GI disturbance 
anterior uveitis and scleritis 
hypertension
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5
Q

systemic manifestations

A
fatigue
fever 
weight loss
anorexia 
anaemia
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6
Q

blood test to remember

A

ANCA

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7
Q

2 types of ANCA

A

c-ANCA and p-ANCA

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8
Q

types of ANCA and what vasculitis associated with

A
p-ANCA = microscopic polyangitis and churg strauss
c-ANCA = wegners
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9
Q

what markers are raised?

A

ESR and CRP

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10
Q

main treatments

A

steroids and immunosuppressants

refer to rheumatology

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11
Q

steroids

A

oral - prednisolone
IV = hydrocortisone
nasal sprays
inhaled - lung

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12
Q

immunosuppressants

A

cyclophosphamide
MTX
azathioprine
rituximab

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13
Q

what type of vasculitis is HSP?

A

IgA

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14
Q

HSP presentation

A

purpuric rash of lower limbs and buttocks

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15
Q

cause of HSP

A

IgA deposits in blood vessels of skin, kidneys and GI tract

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16
Q

HSP trigger

A

upper airway infection eg tonsilitis or gastroenteritis

17
Q

HSP - who it affects

A

children under 10

18
Q

4 classic features of HSP

A

purpura
joint pain
abdominal pain
renal involvement

19
Q

what can HSP do to kidneys?

A

IgA nephritis

20
Q

treating HSP

A

supportive - hydration, analgesia

21
Q

What organs does eosonophilic granulomatosis with polyangitis affect?

A

lung and skin

22
Q

churg strauss presentation

A

severe asthma in late teens or adulthood

23
Q

churg strauss characteristic finding

A

elevated eosinophil

24
Q

features of microscopic polyangitis

A

renal failure

SOB and haemoptysis

25
Q

what does wegners affect?

A

respiratory tract and kidneys

26
Q

common finding of wegners

A

saddle shaped nose

27
Q

wegners symptoms

A

epistaxis and crusty nasal secretions
sinusitis
cough, wheeze, haemoptysis

28
Q

polyarteritis nodosa most associated with?

A

hepatitis B

hep C or HIV

29
Q

polyarteritis nodosa rash

A

livedo reticularis

mottled, purplish, lace like

30
Q

who does kawasaki disease affect?

A

children under 5

31
Q

clinical features of kawasaki

A
persistent high fever 
erythematous rash 
bilateral conjunctivitis
erythema of palms and soles
strawberry tongue
32
Q

key complication of kawasaki

A

coronary artery aneurysm

33
Q

treating kawasaki

A

aspirin and IvIg to avoid carotid aneurysm

34
Q

what vessel does takayasu’s affect?

A

aorta

pulmonary arteries

35
Q

other name for takayasu’s

A

pulseless disease

36
Q

presentation of takayasu’s

A

under age of 40
fever, malaise, muscle aches
arm claudication or syncope

37
Q

diagnosing takayasu’s

A

CT or MRI angiography

doppler USS carotids