Inflammatory muscle disease Flashcards
1
Q
2 types of inflammatory muscle disease
A
polymyositis and dermatomyositis
2
Q
key investigation for diagnosis
A
creatine kinase
3
Q
other reasons for raised ck
A
rhabdomyolysis AKI MI statins strenuous exercise
4
Q
what can often be underlying?
A
cancer - paraneoplastic syndrome
5
Q
what cancers are associated?
A
lung
breast
ovarian
gastric
6
Q
presentation
A
muscle pain, fatigue and weakness
bilateral proximal muscles
shoulder and pelvic girdle
7
Q
dermatomyositis features
A
heliotrope rash gottrons lesions subcutaneous calcinosis erythematous rash periorbital oedema
8
Q
autoantibodies
A
anti Jo1
anti-Mi2
ANA
9
Q
diagnosis
A
clinical
elevated ck
autoantibodies
EMG
10
Q
definitive diagnosis
A
muscle biopsy
11
Q
management
A
physio and OT
CCS
IVIg, azathioprine, infliximab
12
Q
dermatomyositis rash +ve sign
A
shawl sign - flat red rash over neck and back
13
Q
differentials
A
muscular dystrophy
drugs - statins, colchicine
rhabdomyolysis
PMR
