Neuro - Guillain Barre Flashcards

1
Q

what is guillain-barre syndrome?

A

acute paralytic polyneuropathy

affects PNS

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2
Q

PNS or CNS affected?

A

PNS

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3
Q

classical symptoms

A

acute, symmetrical ascending weakness

sensory symptoms

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4
Q

trigger

A

infection - campylobacter jejuni, cytomegalovirus and EBV

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5
Q

underlying pathophysiology

A

molecular mimicry

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6
Q

explain molecular mimicry

A

B cells create antibodies

target proteins on myelin sheath of nerve axon

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7
Q

reflexes

A

reduced

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8
Q

sensation and pain

A

peripheral loss

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9
Q

clinical course

A

within 4 weeks of infection
start in feet and move up
peak 2-4 weeks then recovery

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10
Q

diagnostic criteria

A

brighton criteria

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11
Q

diagnosis

A

brighton criteria
nerve conduction
lumbar puncture

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12
Q

lumbar puncture findings

A

raised protein

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13
Q

management

A

IVIg
plasma exchange
VTE prophylaxis
ICU

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14
Q

prognosis

A

80% fully recover

5% fatal

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15
Q

main causes of mortality

A

PE
respiratory insufficiency
cardiac arrest

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16
Q

epidemiology

A

1-4/100 000

adults