Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Rheumatology > Scleroderma > Flashcards

Scleroderma Flashcards

1
Q

Typical presentation

A

Woman, presenting with Raynaud’s syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Pathophysiology

A

Autoimmune systemic condition
Increased fibroblast activity
Abnormal connective tissue growth
Vascular damage & fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Subtypes

A

Limited SSC
Diffuse SSC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Diffuse SSC features

A

Less common
Increased mortality
Sudden onset skin changes
Proximal joint involvement. (Knees, Elbows)

HTN -> Renal Failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Limited SSC Features

A

More common

Calcinosis Cutis
Raynaud’s Syndrome
Esophageal dysmotility
Sclerodactyly
Telangiectasia

Pulmonary HTN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Investigations Limited SSC

A

ANA Positive
Anti Centromere Antibody

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Investigations diffuse SSC

A

Topoisomerase antibody
Anti RNA Polymerase III Antibody

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

General investigations

A

CXR - Pulmonary disease
Joint XR - Calcinosis Cutis
Echo/ ECG - Arrhythmia, HF, Myocarditis
CRP/ESR/PV - Normal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Treatment

A

NO CURE

  1. Psychosocial
  2. PDE 5 (Sildenafil)
  3. Ace inhibitors (Blood pressure, Renal protection)
  4. Methotrexate, Mycophenolate Mofetil (Skin Thickening)
  5. Prednisolone (Acute flares)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Rheumatology (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions