Giant Cell Arthritis Flashcards
1
Q
Association with which gene
A
HLA-DR4
2
Q
Association with which condition
A
PMR
3
Q
Typical Patient
A
White woman over 50 Years old
4
Q
Presentation
A
Acute onset unilateral headache, Jaw claudication, Scalp Tenderness, Visual disturbances
5
Q
Pathogenesis
A
Inflammation of medium and large sized blood vessels supplying the head and neck.
Including:
Maxillary Artery (Jaw claudication, Tongue discomfort)
Temporal Artery (Scalp Tenderness, Headache)
Central Retinal/ Ophthalmic Artery (Amaurosis Fugax)
6
Q
Investigations
A
Raised CRP, ESR, PV
Necrotising Artery Biopsy
7
Q
Treatment
A
60-100mg Prednisolone PO (3wks)
1g IV Methylprednisolone pulse therapy if jaw claudication of visual disturbances
Aspirin 75mg
