SCI Flashcards
5 risk factors that qualify a patient for 12 weeks (rather than normal 8 weeks) of DVT prophylaxis?
long bone fx, cancer, advanced age, obesity, heart failure
About what percentage of SCI patients with complete injury are able to achive ejaculation?
15% (a little higher with LMN vs UMN)
At what level does the spinal cord end?
L1
common site for osteoporotic fracture in SCI patients?
distal femur
describe posterior cord injury
injury to dorsal columns causing loss of light touch/proprioception and impaired ambulation
Diameter of absolute stenosis in the spinal canal
less that 10mm
Does likelihood of pregnancy after SCI change?
No, fertility is unimpaired
Extradural spinal tumors are commonly metastases from what three areas of the body?
lung, breast, and prostate
female fertility after SCI
normal menstruation returns in 6-12 months so long-term fertility is unaffected
gold standard to dx pulmonary embolism
pulmonary arteriogram
How can you tell the difference between autonomic dysreflexia and preeclampsia?
- AD symptoms occur with contraction of the uterus and normalize with relaxation of the uterus
- Preeclampsia is associated with protein in the urine, elevated uric acid, elevated LFTs, and decreased platelets
How does Brown-Sequard syndrome present?
ipsilateral loss of motor function, light touch/proprioception and contralateral loss of pain and temperature
How does cauda equina differ from conus medullaris syndrome?
Cauda equina is asymmetric, areflexia/hyporefleic, and can involve lumbar roots
How does cauda equina present?
- Lower motor neuron lesions of lumbosacral nerve roots
- Asymmetric flacid paralysis and sensory loss in nerve root distributions
- Areflexic bowel, bladder, and sexual dysfunction
- Positive EMG findings
How does conus medullaris syndrome present?
- UMN or mixed UMN/LMN lumbosacral lesions
- saddle distribution sensory loss
- possible bowel, bladder, and sexual dysfunction
- Normal EMG unless S1 or S2 involvement
How does level of injury affect the ability of SCI patients to have an erection?
- T9 and above: reflexogenic intact, psychogenic lost
- T12 and below: psychogenic intact, reflexogenic lost
- S2-4: reflexogenic impossible, psychogenic greatly reduced
How does subacute combined degeneration present?
insidious onset of sensory symptoms followed bilateral spastic paresis of lower limbs
how does syringomyelia present in the setting of SCI?
insidious onset of ascending loss of reflexes, burning pain worse with sitting or valsalva
How is baclofen cleared from the body?
renally (use lower doses in CKD)
How is diazepam cleared from the body?
hepatically (use lower doses in liver disease)
How long does it take for resolution of areflexic bladder seen in patients with spinal shock?
2 - 12 weeks
In general, are prophylactical antibiotics to treat UTIs in SCI patients indicated?
No
leading cause of death in acute SCI?
pulmonary embolism
leading cause of death in chronic SCI?
pneumonia
leading cause of death in paraplegia?
heart disease
male fertility after SCI
decreased due to poor semen quality and impaired erections
mechanism of action of baclofen
GABA B agonist
mechanism of action of botulinum toxins
the toxin will cleave proteins needed for Ach vesicle fusion with the presynaptic membrane. Depending on the form of toxin, it will cleave syntax, synaptobrevin, or SNAP-25.
mechanism of action of dantrolene
binds to ryanodine receptor on sarcoplasmic reticulum (SR) to inhibit calcium influx from SR in to cell.
mechanism of action of diazepam
GABA A agonist (Cl channel activator)
Mechanism of action of mirabegron?
Beta-3 agonist causing bladder relaxation
mechanism of action of mirabegron?
beta-3 agonist to cause bladder relaxation
mechanism of action of tamsulosin?
alpha-1 blocker causing internal sphincter relaxation
mechanism of action of tizanidine
alpha-2 agonist (inhibits spinal reflex arc)
Mneumonic for remembering Gaba receptor agonist and ion channels
- CLACK
- Gaba A: increase presynaptic Cl into neuron
- Gaba B1: increase presynaptic Ca2+ into neuron
- Gaba B2: increase postsynaptic K out of the neuron
most commmon cause of emergency abdominal surgery in chronic SCI patients?
cholecystitis
most common cause of death in acute SCI
pulmonary embolism
Most common cause of SCI?
MVC
most common level for central cord with hyperextension of the c-spine?
C4-C5
most common level for cervical compression fracture with flexion and axial load?
C5
most common level of injury of paraplegia?
T2
most common level of SCI
C5
most common presentation of myelopathy?
gait disturbance followed by UE paresthesias, decreased fine motor coordination, and hand weakness
most common presenting sign of syringomyelia in SCI patient?
ascending loss of deep tendon reflexes
Most common site for heterotopic ossification in SCI patients?
Hip
Most common site for pressure injuries in children?
occiput
Most common site for pressure injuries in SCI patients?
sacrum
most common presenting symptom of syringomyelia in SCI patient
aching/buring pain worse with coughing or straining
most common timing of DVT related to SCI
in the first two weeks
most common to least common type of SCI
incomplete tetra, incomplete para, complete para, complete tetra
most common type of multiple sclerosis
relapsing-remitting
Most common type of neurogenic bladder seen in SCI?
DSD (detrusor-sphincter-dyssynergia)
What are the key muscles and their root level for the ASIA exam?
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What are key sensory points for the ASIA exam?
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onset, peak, and duration of action of botox
3 days, 3 weeks, 3 months
Pressure injury staging
- nonblanchable erythema 2. into dermis 3. through dermis 4. muscle, tendon, or bone exposed
Receptor type in bladder wall that allow for contraction?
ACh
Receptor type in bladder wall that allows for relaxation?
Beta-2
Sympathetic nerve that allows for bladder storage?
Hypogastic nerve (T11 - L2) “makes bladder as big as a Hippo”
Treatment for hypercalcemia in SCI patients?
IV fluids (increases urinary excretion) or Pamidronate (inhibits osteoclast-mediated bone resorption)
Treatment for neuromyelitis optica?
IV glucocorticoides, may follow with plasmapheresis
treatment for vertebral body compression fractures
Jewett or CASH brace to limit hyperflexion
Treatment options for adynamic ileus after SCI?
NGT, IVF, metoclopromide, erythromycin, neostigmine
two common tendon transfers for C5 SCI patient?
- brachioradialis to ECRB
- deltoid to triceps
type of lung pattern seen in SCI patients?
restrictive (all volumes decreased except residual volume)
What allows parasympathetic micturition action?
sacral micturition center
What are common vital sign findings in autonomic dysreflexia?
hypertension and bradycardia
What are four pharmacologic agents (and their associated mechansims) used to treat orthostatic hypotension in SCI patients?
- salt tabs
- midodrine (alpha-1-agonist)
- fludrocortisone (mineralocorticoid)
- droxidopa (norepinephrine pro-drug that can cross the blood-brain barrier)
What are the earliest changes seen in neurogenic bladder?
irregular thickend bladder wall with small diverticuli
What are the three phase of a triple phase bone scan?
- blood flow phase: check for vasoconstriction or dialation
- blood pool phase: check for edema
- delayed tracer uptake: indicates osteoblastic activity or bone turnover
What are three causes of incomplete spinal cord injuries?
- unilateral facet joint dislocation
- fall in the setting of cervical spondylosis
- gsw or stab wound that does not penetrate the spinal canal.
what are three reasons to treat an asymptomatic UTI in an SCI patient?
- pending bladder study,
- bladder pathology such as VUR
- growing urease-prodding bug
what are three risk factor for epidural abscess?
IVDA, diabetes, immunocompromised
What are three alpha-1 agonists that can be used to treat retrograde ejaculation?
midodrine, imipramine and pseudoephedrine
What are two areas to commonly see MS lesions
spinal cord, periventricular region
what are two uses for E-stim in SCI patients
- to move a extremity for functional activity
- to avoid complications of muscle inactivity
What bacteria is the most common cause of epidural abscess?
Staph aureus
What can cause abdomina pain, nausea, and vomiting after rapid weight loss and prolonged supine position?
Superior mesenteric artery syndrome: duodenum is intermittently compressed between the SMA and aorta
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What coordinates bladder contraction with internal urethral sphincter relaxation?
pontine micturition center
what direction does syringomyelia progress in the spinal cord?
cephalad and caudal
what finding is associated with a good prognosis in multiple sclerosis?
optic neuritis
What is a Chance fracture?
transverse fracture of the thoracic or lumbar spine from posterior to anterior
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what is a common level in the cervical region for facet dislocation?
C5-C6
What is a Hangman fracture?
C2 burst fracture due to rapid decelerations injury of the head
What is a Jefferson fracture?
C1 burst fracture due to high impact axial load
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What is a key difference between sildenafil (Viagra) and tadalafil (Cialis)?
Duration of action is longer with tadalafil (up to 36hrs) vs about 5 hours with sildenafil
What is a quick way to tell if a patient is ASIA A?
“NOON” sign on ASIA sheet
What is an ASIA B?
- “Sensory Incomplete”
- Intact sensory at S4-S5 or deep anal pressure
- No motor function more than three levels below motor level.
What is an ASIA C?
- “Motor Incomplete”
- Less than half of key muscles have a grade of at least 3/5
- Either voluntary anal contraction OR patient meets criteria for ASIA B with exception of motor function preserved more than 3 levels below the motor level (includes non-key muscles)
What is an ASIA D?
- Motor incomplete
- Meets criteria of ASIA C with exception of at least half (half or more) of key muscles are at least 3/5.
What is detrusor sphincter dyssynergia?
lack of coordination between pontine and sacral (S2-4) micturation centers due to neurological injury causing high bladder pressures and increased risk for reflux
What is first and last to recover in central cord syndrome?
- first to recover - lower extremity function
- last to recover - intrisic hand function
What is Lhermitte sign?
passive neck flexion causes shooting electrical pain in the neck and shoulders. classically seen in MS
What is LMN bladder?
flacid bladder causing overflow incontinence. Cannot urinate due to blocking of sacral micturition center
What is neuromyelitis optica?
An immune mediated combination of optic neuritis and transverse myelitis
What is recommended during delivery of the baby in a pregnant SCI patient?
spinal anesthesia if injury is at T6 or above
What is seen on CSF studies in MS?
oligoclonal IgG bands (markers of CNS inflammation)
What is seen on radiographs with vertebral body compression fractures?
anterior wedging, sometimes retropulsed bony fragments into spinal canal
What is spinal shock?
absence of all spinal reflex activity below level of injury for 24 hours
What is the “3-2-1” bowel program?
- colace 100mg 3 x a day
- senna 2 x a day
- suppository (dulcolax or magic bullet) 1 x a day after meal
What is the bulbocavernosus reflex and its significance?
- squeezing tip of penis/clitoris causes anal sphincter contraction
- absense after 24hrs indicates lower motor neuron injury (unlikley to get reflexogenic erection)
What is the cause of detrusor overactivity in upper motor neuron bladder (lesion above S2)?
lack of descending inhibition of sacral micturition center
What is the cause of retrograde ejaculation in SCI patients?
lack of coordination between urinary sphincters ie abnormally open internal and closed external sphincter
What is the etiology of autonomic dysreflexia?
noxious stimulus below level of injury causes sympathetic output, baroreceptors sense increased BP however signal from the brainstem to decrease sympathethic outflow and allow vasodilation is blocked in the spinal cord
What is the fasciculus gracilis?
medial dorsal column providing light touch and vibration sensation to the leg
What are the steps in treatment of autonomic dysreflexia?
- sit the patient up and loosen clothing
- flush indwelling catheter, look for other noxious stimulus
- monitor BP every 5 minutes
- treat with nitropaste (1/2” to start) or clonidine (0.3mg) before checking for fecal impaction
- monitor for recurrent symptoms for at least 2 hours after resolution
What is the highest ASIA A level for being modified independent with driving?
C5
What is the highest possible ASIA A level that can live independently?
C6 (extremely motivated)
What is the mechanism for a cervical compression fracture?
axial load with the neck flexed
What is the mechanism for orthostatic hypotension in SCI patients?
lack of vasoconstriction due to block in sympathetic outflow
what is the mechanism for spasticity in SCI?
loss of descending inhibition of spasticity arc
What is the mechanism of injury that will cause central cord syndrome?
excessive hyperextension (fall on outstretched chin)
What is the most common cause of autonomic dysreflexia?
bladder overdistention or infection
What is the most common cause of progressive myelopathy after SCI?
syringomyelia
What is the most common medical complication after SCI?
UTI
What is the most common type of dens (odontoid) fracture?
Type 2 (fracture through the base), often requires surgery
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What is the most restrictive removable cervical brace?
Minerva brace
What is the usual ASIA A level for achieving independence?
C7
What is UMN bladder?
spastic bladder due overactive detrusor caused by loss of descending inhibition to sacral micturition center from the frontal lobe and pontine micturition center.
What vertebral level does cauda equina occur at?
below L1-L2
What level of SCI are at risk for impaired temperature regulation?
T8 and above
What level of SCI can ambulate with assistive devices?
T10
What level of SCI injury puts a patient at risk for autonomic dysreflexia?
T6 and above
What long tracts in the spinal cord have both lateral and anterior/ventral locations?
- corticospinal (lateral and anterior)
- spinothalamic (lateral and ventral)
- spinocerebellar (lateral and ventral)
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What nerve fiber is critical for a psychogenic errection?
hypogastric nerve (T11-L2, sympathetic)
What nerve fiber is critical for a reflexogenic erection?
pelvic nerve (S2-4, parasympathetic)
What percentage of SCI patients develop detrusor sphinceter syssynergia?
85%
What percentage of SCI patients have returned to work at 5 years post injury
25%
What portion of SCI patients develop upper extremity compression neuropathies?
Nearly 2/3
What provides innervation to the external urethral sphincter?
pudendal nerve (S2- S4) - voluntary action
What provides parasympathetic innervation to the bladder and bowel?
pelvic nerve “parasympathetics pee pelvic”
What three nerves innervate the bladder and sphincter?
- pudendal (somatic)
- pelvic (parasympathetic, S2-4, cholinergic receptors)
- hypogastric (sympathetic, T11-L2, alpha-1, beta-2/3)
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What two ADL areas can a ASIA C4 be modified independent?
weight shifts and wheelchair propulsion (both in a power WC)
What type of exercise is recommended for MS patients?
submaximal
When can you wean an SCI patient off a ventilator?
Vital capacity > 15-20 ml/kg
When does hypercalcemia present in SCI patients?
usually 4 to 8 weeks post injury
When is a patient not a candidate for phrenic nerve pacing?
There is damage to the phrenic nerve nucleus or C3-C5 nerve roots
When is onset of heterotopic ossification most commonly after SCI injury?
2 months
When should you consider mechanical ventilation in an SCI patient?
- Vital capacity < 1L
- PO2 < 50 mmHg
- PCO2 > 50 mmHg
where is the watershed region between the anterior spinal artery and artery of adamkiewicz?
lower thoracic region
Why are lumbar root unaffected in conus medullaris syndrome?
They have already come off the cord at this point
Why does bladder wall hypertrophy increase the risk of vesicoureteral reflux?
With hypertrophy, the distal ureter goes from traveling up into the bladder to more horizontal. This prevents normal closure of the one-way valve on the inner surface of the bladder wall.
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Why is birth control problematic in women with SCI?
- OCPs raise risk of thromboembolism (avoided in first year after injury)
- IUDs can increase risk for pelvic inflammatory disease and related autonomic dysreflexia
Women with SCI injury above what level are at risk to not percieve uterine contractions and have AD be the only sign of labor?
T10
work-up for suspected syringomyelia
MRI with contrast