Schultz-Oct 2 Flashcards
1
Q
Function of CTD in RNAPII
A
It can be phosphorylated and act as platform for assembly of TFs
2
Q
How many subunits does RNAPII have?
A
12
3
Q
How many subunits does RNAPI have
A
14
4
Q
Does RNAPI large subunit have CTD?
A
No
5
Q
Proteins of RNAPI (x5)
A
Rrn3, UBF, TBP, TFIIH, TTF-1
6
Q
Rrn3 function
A
associates with RNAPI, helps with transcription
7
Q
UBF function
A
- upstream binding factor
- DNA-binding protein
8
Q
TBP
A
forms SL1 complex
9
Q
SL1 complex
A
TBP+TAFs
10
Q
TFIIH function (x2)
A
- RNAPII elongation
- Transcription-coupled DNA repair
11
Q
TTF-1 function
A
binds to sequence elements for termination
12
Q
What is the dimerization domain of UBF?
A
NTD
13
Q
Which HMG boxes interact with DNA?
A
first three
14
Q
How many copies of SL1 per promoter?
A
2
15
Q
Enhancesome
A
1 UBF dimer plus DNA it is bound to in circular configuration
