Schultz-Oct 16

Question 1

Function of non-catalytic subunits of HAT complexes?

Answer 1

confers ability to acetylate nucleosomes

Question 2

What aa do non-catalytic subunits alter?

Answer 2

Lys

Question 3

How does histone modification affect chromatin function?

Answer 3

• alters electrostatic charge of histones

- modification is component of binding surface recognized by chromatin regulating protein

Question 4

All chromatin remodelling complexes have ___ subunit

Answer 4

DNA-dependent ATPase subunit

Question 5

3 outcomes of histone remodelling

Answer 5

• altered accessibility of DNA
• nucleosome sliding
• histone eviction/replacement