Schizophrenia

Question 1

Four symptom domains of schizophrenia

Answer 1

cognition, perception, emotion, and motor

Question 2

Cognition

Answer 2

abnormal speech (form),
delusions (content),
abnormalities in executive and social behavior (alogia, dressing unconventionally, looking disheveled, erratic/compulsive behavior)

Question 3

Perception

Answer 3

Hallucinations

Question 4

emotion

Answer 4

flat effect & anhedonia

Question 5

Motor

Answer 5

Catatonia
decreased motor activity
decreased engagement
excessive/peculiar motor activity

Question 6

criterion A

Answer 6

two or more of the following symptoms:

• Delusions
• Hallucinations
• Disorganized speech
• Grossly disorganized or catatonic behavior
• Negative symptoms (flat affect, anhedonia, etc)

At least one of the symptoms must be delusions, hallucinations, or disorganized speech

Question 7

Criterion B

Answer 7

Social/occupational dysfunction in one or more major areas
* Work
* Interpersonal Relations
* Self-care
* Failure to achieve expected level of functioning (childhood/adolescence
diagnosis)

Impairment is REQUIRED

Question 8

Criterion C

Answer 8

Continuous signs of disturbance present for at least 6 months:

• Criterion A has to be met for at least one month
• May include periods of prodromal or residual symptoms. This might
  include:
• Only negative symptoms
• Attenuated (less-intense) versions of positive symptoms
• Cognitive and/or social problems

Question 9

violence in schizophrenia

Answer 9

Disorganized thought/behavior can make it difficult to carry out major acts of violence
* More likely to be victims of violence, than to commit violent acts
* More likely to be violent than general population, especially those who
abuse substances

Question 10

Schizophrenia epidemiology

Answer 10

one year incidence: 14
one year prevalence: 198
Lifetime prevalence: 340
Lifetime morbid risk: 860

onset is usually in teens & 20s

Question 11

incidence

Answer 11

rate of individuals developing the disorder in a given period of
time

Question 12

prevalence

Answer 12

rate of individuals having the disorder when assessed

Question 13

Lifetime prevalence

Answer 13

rate of individuals who ever had the disorder at time of assessment

Question 14

lifetime morbid risk

Answer 14

probability that an individual will develop the disorder in his/her lifetime

Question 15

Etiology in schizophrenia

Answer 15

Historical View: schizophrenia is caused by bad parenting ( Schizophrenogenic
mother )
* Present View: Very difficult to identify the effects of the rearing environment on schizophrenia risk

schizophrenia is genetic

Question 16

VCFS

Answer 16

• Developmental disorder causing cleft palate, cardiovascular abnormalities,
  and learning disabilities
• Associated with rare ~ 3 Mb deletion on 22q11(~ 30 genes)
• 20%-30% have a psychotic disorder– schizophrenia, schizoaffective –
  accounting for as much as 1% of SZ
• Mice deleted for this region have impaired learning and sensorimotor
  gating