schizophrenia Flashcards

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1
Q

what is schizophrenia

A

a serious mental disorder, 1% of population more common in men and low social economic groups, symptoms can interfere with everyday tasks, meaning schizophenics can often become hospitalized

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2
Q

how do you diagnose schizophrenia

A

need to distinguish 1 disorder from another, so, identidy clusters of symptoms that occur together and classying this as a disorder. Diagnosis is possible by identifying symptoms and deciding what disorder person has

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3
Q

what are the 2 major systems for classification of mental disorder

A

ICD-10 and DSM-5

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4
Q

how do ICD-10 adn DSM-5 differ in classification for schizophrenia

A

DSM-5, a positive symptom (add to normal function) must be present for diagnosis but 2 or more negative symptoms (taken away from normal function) are sufficient in ICD-10

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5
Q

what are positive symptoms of schizophrenia

A

additonal experiences beyond those of ordinary existence like hallucinations and delusions

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6
Q

what are hallucinations

A

unusual sensory experiences, some are related to events in environment but others have no relationship to this (eg. voices heardeither talking to or commenting on a person), can be experienced in relation to any sense, e.g. person may see distored facial expression or animals which aren’t there

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7
Q

what are delusions

A

aka paranoia, they are irrational beliefs. (e.g. thinking your an important historical figure or thinking government is aliens). Delusions make people believe their acting normally but other will think it’s bizzare

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8
Q

what are negative symptoms of schizophrenia

A

loss of usual abilities and experiences like speech poverty and avolition

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9
Q

what is speech poverty

A

reduction in amount and quality of speech and often accompaied by delay in persons verbal response in conversation. Also speech disorganisation where speaker chances topic mid sentence (but this is classified as a positive symptom by DSM-5)

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10
Q

what is avolition

A

apathy, finding it difficult to begin or keep up with goal directed activity (actions performed to achieve a result), schizophrenics have reduced motivation to do a range of activities. 3 signs of avolition are poor hygiene and grooming, lack of persistence and lack of energy

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11
Q

what is family dysfunction

A

psychologists have attempted to link schizophrenia to childhood and adult experiences of living in dysfunctional family

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12
Q

what is the schizophrenogenic mother

A

Fromm-Reichmann proposed psychodynamic explanation for schizophrenia based on accounts from her paitents childhood. She noted many paitents refered to one parent (who she called the schizophrenogenic mother-schizophrenia-causing)

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13
Q

according to Fromm-Reichmann how does the schizophrenogenic mother cause schizophrenia

A

they are cold, rejecting and controlling and creates family tension and secrecy which leads to distrust that later develops into paranoid delusions and ultimately schizophrenia

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14
Q

what is double-bind theory

A

Baterson et al agreed family climate is important in schizopohrenia but emphasised role of communication style in family. Child often finds themselves trapped in situation where they fear wrong-doingbut receive mixed messages about what it is and feel unable to comment on unfairness of situation or seek clarification and when child is wrong punished by withdrawal of love.

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15
Q

what happens in double-bind when condiitonal love occurs

A

understanding of the world is confusing and dangerous and reflected in symptoms like disorganised thinking and paranoid delusions. Baseson said this was neither main type of communication in family of someone with schizophrenia or only factor in developing schizophrenia, just a risk factor

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16
Q

what is expressed emotion in family dysfunction

A

EE is level of emotion, especially negative, towards person with schizophrenia by their carers

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17
Q

whar are the elements of expressed emotions

A

verbal critism, occasionally with violence, hostility towards person, including anger and rejection and emotional overinvolvement in life of person, including needless self-sacrifice

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18
Q

how does expressed emotion cause schizophrenia

A

high levels of expressed emotions directed towards individual is source of stress and explains relaapses in schizophrenia but it can also be a source in someone who is already genetically vulnerable (diathesis-stress model)

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19
Q

what is dysfunctional thinking in cognitive explanations

A

schizophrenia categorised as disruption to normal thought processing which we can see in many of its symptoms. Reduced thought processing in ventral striatum associated with negative symptoms but reduced processing of information in temporal and cingulate gyri associated with hallucinations, this is lower than usual level of info processing so cognition is likely to be impaired

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20
Q

what is congitive explantion for schizophrenia

A

focuses on role of mental processes, schizophrenia associated with a few types of dysfunctional thought processing

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21
Q

what is meta representation dysfunction in cognitive explanations

A

Frith et al idenfied 2 dysfunctional thought processes, first is metarepresentation, cognitive ability to reflect on thoughts and behaviour allowing insight into our intentions and goals and interpret others actions. Dysfunctional metarepresentation impacts our ability to recognise are own actions and thoughts as being carried out by ourselves not someone else, explaining hallucinations of hearing voices and delusions

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22
Q

what is central control dysfunction

A

Frith et al identified issues with cognitive ability to suppress automatic responses while we perform deliberate actions. Speech poverty and thought disorder could result from inability to suppress automatic thoughts and speech triggered by other thoughts (e.g. people with schizophrenia tend to experience derailment of thoughts as each word triggers association and can’t suppress automatic response to these

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23
Q

what is a strength of family dysfubnction

A

evidencing linking it to schizophrenia. Indicators of family dysfunction include insecure attachment and exposure to childhood trauma, esp abuse. Read et al found adults with schizophrania are disproportionally likely to have insecure attachment, type C or D and also reported 69% or women and 59% men have history of physical and/or sexual abuse. Morkved et al found most adults with schizophrenia reported 1 childhood trauma, mostly abuse. This suggests family dysfunction makes people more vulnerable to schizophrenia

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24
Q

what is a limitation of family dysfubnction

A

poor evidence for this explanation. Almost no evidence supporting importance of traditional family based theory like the schizophrogenic mother and double bind. Both these theories based on clinical observations of shcizophrenics and informal assessment of mothers personalities but not systematic evidence. This means family explanations have not been able to account for link between childhood trauma and schizophrenia

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25
Q

what is a strength of cognitive explanations

A

evidence for dysfunctional throught processing. Stirling et al compared performance on range of cognitive tasks in 30 people with schizophrenia and a control group of 30 people without schizophrenia, including Stroop tasks. Found firth et al central control theory was accurate, people with shcizophrenia tooklonger. This means cognitive process of people with schizophrenia is impaired.

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26
Q

what is a limitation of cognitive explanations

A

they only explain the proximal origins of symptoms because they explain what is happening now to produce symptoms (instead of distal explanations which focus on what initially causes the condition). Possible distal explanations are genetic and family dysfunction. What is unclear atm is how genetic variation or childhood trauma might cause problems with metarepresentation or central control. This means cognitive theorieson their own only provide partial explanations for schizophrenia.

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27
Q

what does most common schizophrenia treatment involve

A

use of antipsychotics

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28
Q

what does antipsychotic refer to

A

psychosis, person with psychosis experiences some loss of contact with reality through hallucinations or delusions

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29
Q

How long are antipsychotics taken for

A

can be short or long term, antipsychotics can also be divided into typical (traditional) and atypical (second generation drugs)

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30
Q

what are typical antipsychotics

A

have been around since 1905 including chlorpromazine taken as tablets, syrup or injection. Dosages are gradually increased the longer the drug has to be taken but the use of typical drugs for schizophrenia has decreaased in last 50 years

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31
Q

what is dopamine anatagnosists in typical antipsychotics

A

strong association between use of typical antipsychotics (chlorpromazine) and dopamine hypothesis. Typical antipsychotics work by acting as antagonists in dopamine system, anatgonists are chemicals that reduce action of a neurotransmitter. Dopamine anatgonists work by blocking dopamine receptorsin synapses, reducing dompaime action. Initially when you strat on the drug dopamine levels build up but then they reduce. According to dopamine hypothesis of schizophrenia this dopamine-anatgonist effect normalises neurotransmittion in key areas of brain and reduces symptoms like hallucinations

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32
Q

what is sedation effect

A

as well as antipsychotic proterties typical drugs (chlorpromazine) is an effective sedative. This is related to the histamine receptors but not fully understood how it causes sedation. Typical drug oftyen used to calm individuals not only with schizophrenia but with other conditions, has been done when paitents first admitted to hospital and are very anxious

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33
Q

what are atypical antipsychotics

A

Aim in developing newer antipsychotics to maintain or imrpove effectiveness of drugs in supressing psychosis symptoms and minimises side effects of drug used, range of atypical antipsychotics and they all work differently

34
Q

what is clozapine

A

Withdrawn at the begining as it caused death of some ptients form lood condition called agranulocytosis, but, later it was discovered it was more effective than typical antipsychotics and used when these typical antipsychotics failed, it is still used like this today and paitents using it have regular blood tests to ensure they’re not developing agranulocytosis. Because of its potentially fatal side effects dose is very small

35
Q

how does clozapine wokr

A

it binds to dopamine receptors same was as chlorpromazine but it also acts on serotnin and glutamate receptors, this helps improve mood and reduce depression and anxiety and may improve cogntiive functioning. Mood enhancing effects of clozapine mean its sometimes given if patient is a suicide risk

36
Q

what is risperidone

A

only recently developed, developed to attempt to produce drugs as effective as clozapine without serious side effects. It can be taken in tablet, syrup or injection. Small dose is initially given and then builds up overtime.

37
Q

how does risperidone work

A

binds to dopamine and serotonin receptors, it binds more tightly to dopamine receptors than clozapine and is therefore effective with smaller doses and some evidence showing it leads to fewer side effects than other antipsychotics

38
Q

what is a strength of drug therapy

A

support for antipsychotic effectiveness in tackling symptoms. Thornely et al reviwed studies comparing effects of chlorpromazine to control conditions, data form 13 trials with 1121 participants showed better overall functioning and reduced symptoms compared to placebo. Also, reviewed found chlozpine (atypical) is more effective than typical treatments. This means antipsychotics work

39
Q

what is coounterpoint of drug therapy

A

Healy suggested flaws in evuidence of antipsychotic effectivness. E.g. most study short term effects. Also, as antipsychotics have powerful claming effects its easy to demonstrate they have posiitve effects on people with schizophrenia symptoms, which isn’t same as saying it reduces psychosis. Means evidence base for antipsyhcotics effectuvenesss is less impresive than thought.

40
Q

what is limitation of drug therapy

A

side effects. Typical antipsychotucs associated with dizziness, agitation, sleepiness, weight gain, itchy skin. Long term use2 can cause tarduve dyskinesia (caused by dopamine super sensitivity and causes involontary facial expressions). Most severe side effect is NMS which can cause high temp, delirium, coma and can be fatal but is rare. This means antipsychotics do harm as well as good.

41
Q

what is furhter limitation of drug therapy

A

don’t know why they wok. It is thought they work as schizophrenia is linked to high levels of dopamine in subcortex of brain but the dopamine hypothesis is not a complete explanation for schizophrenia and there are alternative hypothesis which suggest antipsychotics shouldn’t work. As we don’t know how they work it leads to conclusion that they’re ineffective. Means some antipsychotics may not be best treatment for schizophrenia.

42
Q

what is CBT

A

commuly used to treat schizophrenia taking place over 5-20 sessions either in gorups or alone and aims to tackle cognitons and behavoiur

43
Q

how does CBT help w schizophrenics

A

can help a client make snese of their irraitional cogntiions (delusion, hallucinations) impact on their feeloings and behvaours, just undestanding the symptoms can be very useful for those w symotoms like auditiory hallucinations, it doesn’t eliminate symptoms but makes people able to cope woth them which reudces stress and increases ability to function adequatly

44
Q

what is normalisation in CBT for schizophrenia and how are delusions takckled in CBT

A

people hearing voices helped by teaching them voice hearing is an extrension of ordinray experience of thinking in words, delusions also challengedd by realty teasting where therapist and client joinly evaluate the likelyhood of their delusions, if this doesn’t work CBT can still be used to tackle anxiety ans depression from having schizophrenia

45
Q

what is family therapy for CBT

A

takes place with famlies and identified patient (member of dysfunctional family w schizophrenia). Aims to improve communication quality and interactions between family members, range of techniques in family therapy.

46
Q

how does family therapy help

A

Pharoah et al identified a range of strategies that family therapists use to try to improve functioning of family that has member w schizophrenia by reducing negative emotions and imoprve families ability to help

47
Q

what is reduce negatuve emotions in family therapy

A

aims to reduce levels of expressed emtions, especially negative emtions like anger and guilt which create stress, reducing stress is useful to prevent relapse

48
Q

what is imprve family ability to help in family therapy

A

theraqpist encourages family members to form therapeutic alliance where they all agree on therapy aims and try to improve beliefs and behaviours to schizophrenia. Also, aim to achieve balance between caring for member with schizophrenia and maintaining their own life

49
Q

what model did Burbach propose for families with a schizophrenic member

A

begins with sharing basic info and and providing emotional + practical support. Develops through progressively deeper levels. Phase 2 is identifying resources like what different members can offer. Phase 3 encourages mutual understanding creating safe space for all members to express their feelings. Phase 4 identify unhelpful patterns of interaction. Phase 5 about skill training like stress management. Phase 6 relapse prevention. Phase 7 maintenance for future.

50
Q

what is strength of CBT

A

evidence for its effetuveness. Jauhar et al reviewed 34 studies of CBT for schizophrenia and concluded there is evidence for significant effects on positive and negative symptoms. Pontillo et al found reduction in severity of audioty hallucinations and NICE recommended CBT for scizophrenia. This means both research and clinical experience support benefits of CBT

51
Q

what is limitation of CBT

A

Wide range of techniques and symptoms included in studies, each vary case from case. Thomas said different studies involved use of different CBT techniques and people with different combos of positive and negative symptoms. Overall modest benefits conceal wide variety of effects of different CBT techniques and different symptoms. This means hard to say how effective CBT for schizophrenia is.

52
Q

what is strength of family therapy

A

evidence for effectuveness. McFarlane said family therapy was most consistently effective treatments for schizophrenia. Esp relapse rates were found to be reduced by 55% on average and NICE recommend family therapy for all diagnosed w schizophrennia. Means family therapy is beneficial esp in preventing relapse

53
Q

what is further strength of family therapy

A

benefits all family members. Therapy is not just for identified patient but for those who care for them. Lobban et al concluded this is important as family will provide better care. By strengthening functioning of whole family, lessens negative impacts of schizophrenia on other members and strengthens ability to help identified patient. Means family therapy has wider benefit beyond just the schizophrenic patient.

54
Q

what are tocken economies for schizophrenia

A

reward systems used to manage behaviour of people w schizophrenia, esp those who have developed patterns of maladaptive behaviour through spedning lots of time in psych ward

55
Q

what was an example of token economy for schizophrenia by Ayllon et al

A

trialled token economy on ward with schizophrenic women, every time participant did task like making their bed or cleaning up the were given a plastic token saying ‘one gift’. These were swapped for ward privileges like watching a film. Number of tasks carried out increased significantly

56
Q

when were token econmies used and why no longer

A

in 1960-70s when norm for treating sschizophrenia was LT hospitalisation. Now use has declined as growth in community based care and closure of many psych hospitals and due to ethical issues of restricting rewards to people w mental disorders

57
Q

when does institutionalisation develop

A

after prolonged hospitalisation

58
Q

what are outcomes of institutionalisation

A

people develop bad habits like no longer maintaing good hygiene or socialsing w others whcih is understandable when living without routine and small plesures we have in everyday life.

59
Q

what are the 3 behaviours Matson et al identified of institutional behaviour tackled by token economy

A

personal care, condition relted behaviours (apathy), ocial behavoiur

60
Q

what are the 2 major benefits of modifying behaviours said by Maston et al although doesn’t treat SZ

A
  1. improves person quality of life within hospital setting, e.g. make-up for someone who takes pride in their appearance 2. normalises behaviour and makes it easier for those whose spent long time in hospital to adapt back into normal life, e.g. getting dressed in morning
61
Q

what is involved in token economy

A

tokens (form of coloured disc) are immediately given to partiicapnt once comlpeting desirable behaviour. Target behaviours are decided on individual basis and must know person to decide apporiate targets for them. These tokens although having no value are swapped for rewards but the immediate rewards of tokens are necessary as delayed rewards are less effective. So, tokens are given as soon as possible after target behaviour done. Rewards in hospital may be sweets or magazines or activities like film or walk outside or appointment w social worker to plan for life after hospital

62
Q

what is the idea behind token econmies

A

theu are a type of behaviour modification based on opernt conditioning. Tokens are secondary reinforcers as only have value once person recieving it realises they’re used to get meaningful rewards which are primary reinforcers. For tokens to become secondary reinforcers they are paired w primary reinforcers, so at start these tokens and primary reinforcers are adminsitered together

63
Q

what is strength of token economy for schizophrenia

A

evidence of effectuveness. Glowacki et al found 7 high quality studies that examined effectiveness of token econmmy for people wiht chronic mental health issues like schizophrenia and involved hospitalised paitents. All studies showed reduction in negative symptoms and decline in unwanted behaviours. Supports token economies value

64
Q

what is counterpoint of token economy for schizophrenia

A

7 studies is small amount of evidence to support effectuveness of a technique. This causes a file drawer problem as it may be onnly posiitve studies have been published and undesirable ones have been filed away. This is often a problem in reviews with a small number of studies. Means questions over evidence of token economies effectivenss

65
Q

what is limitation of token economy for schizophrenia

A

ethical issues raised. Gives professionals power to control their pateints. Token econmy involves imposing 1 persons norms to another. For example, it may restrict the ability of pleasures (seeing films) to people who are already having disressing symptoms, making it an even worse time. This is one reason of the decline of token econmies, esp as many families have taken legal action against this. Means benefits of token econmy don’t outweight impact on personal freedom and ST reduction of quality of life

66
Q

what is further limitaion of token economy for schizophrenia

A

existance of more ethical/pleasant alternatives. Other options that raise fewer ethical issues. E.g. Chiang et al concluded art therapy may be good alternative, evidence base is small but shows it is a high gain, low risk approach to managing schizophrenia and it is pleasant withoout any risk of side effects of ethical abuse. NICE recommend art thersapy for SZ. Means art therapy may be good alternative to token economy.

67
Q

what is interactionist approach

A

approach that acknowledges there are biological, psychological and social factors in development of schizophrenia

68
Q

what are biological factors in schizophrenia

A

genetic vulnerability, neurochemical and neurological abnormalities

69
Q

what are psychological factors in schizophrenia

A

stress resulting from life events and dsily hassles

70
Q

what are social factors in schizophrenia

A

poor quality interactions in the family

71
Q

what is the daithesis stress model

A

diathesis-vulnerability, stress-negative experience, Diathesisn-stress says both a vulnerability to schizopjrenia and a stress trigger are necessary to develop the disorder, 1 or more underlying factors make a person particularly vulnerable to developing schizophrenia but onset of condition is triggered by stress

72
Q

what is Meehl’s model in interactionist approach for Sz

A

in original diathesis-stress model vulnerability was entrily genetic (from 1 schizogene), which led to idea of biologically based schizotypic personality, 1 characterostic being sensitve to stress. Mheel said if person doesn’t have schizgene no amount of stress will trigger Sz, but, carriers of gene, chronic stress through childhood and adolescence, e.g. schizophrenogenic mother could result in development of disorder

73
Q

what is our modern understanding of diathesis

A

now understood that many genes each increase genetic vulnerability only slightly, no single schizogene. Also diathesis also includes psychological trauma, so trauma is now condisered diathesis not stress.

74
Q

what did Read et al propose in modern understanding of diathesis

A

a neurodevlopment model in which early trauma alters the developing brain, early and severe trauma like child abuse can seriously affect many aspects of brain development, e.g. hypothalamic-pituitary-adrenal (HPA) system can become overactive making a person more vulnerable to stress later§

75
Q

what is modern understanding of stress

A

stress was originally seen psychological in nature, although psychological stress like from parently may still be important, modern definition includes anything that risks triggering schizophrenia. E.g. Cannabis use (cannabis is stressor as it increases risk of schizophrenia). May be because cannabis interfers with dopamine system but most people do not develop schizophrenia after smoking as they lack vulnerability factors

76
Q

What are treatments for Sz according to interactionist model

A

compatable w both biological and psychological factors. E.g. combining antipsychotics and psychological therapy, CBT.

77
Q

what did Turkington say about treatments from interactionist model

A

possible to believe in biological causes of Sz and still use CBT to relieve psychological symptoms, but, this requires adopting interactionist model

78
Q

difference in Sz treatment in UK and US

A

UK- cobone antipsychotics w CBT, US less use of CBT more biological based lesson use of interactionist approach

79
Q

whta is strength of interactionist approach

A

evidence supporting both vulnerability and triggers. Tienari etal investigated impoact of both genetic vulnerability and psychological triggers. It followed 19000 finsih children whose biological mothers had been diagnosed w Sz. In adulthood high genetic vulberability compared to control of adoptees w no family history of Sz (low genetic vulnerability). Adoptive parents child reering style assessed and found high levels pof critism and hostiility were associated with Sz development, but only in high genetic risk group. Shows combination of genetic vulnerability and family stress can lead to greatly increased Sz risk.

80
Q

whta is limitation of interactionist approach

A

original diathesis stress is too simplistic. Diathesis portrayed as single schizogene and stress as schizophrengenic parenting. Now found multiple genes lead to Sz and stress can come in many different forms. Diathesis can aslo be influenced by psycholoigxal factors and stress can be biological. E,.g. Huston et al found child abuse and cannabis use arr major triggers for Sz. Means muktiple facotrs affecting diathesis and stress not accounted for in orginal model

81
Q

whta is further strength of interactionist approach

A

cobination of biological and psychologcxal treatments. Acknowlediong ths has practocal applciation for combining drug treatments and psychological therapies . Studies that show combing treatmrents enhances theiur effectiveness. E.g. Tarrier et al randomly alloctaed 315 participants to 1. medication + CBT, 2. medicaion + counselling, 3. Medication only (control). Participants in group 1 and 2 showed less symptoms than control. Means clear practocal advantages to adopting interactionist apprach.

82
Q

whta is counterpoint of interactionist approach

A

Jarvis and Okami said a successful treatment for mental disoprders justifies a particular explanation is logical equivilent to saying alchol reduces shyness. Logical error is called treatment-causation fallacy. So we can’t automatically assume successful cobonation of treatments means intercationist approach correct.