schizo

Question 1

what are comorbid conditions with schizophrenia

Answer 1

1. depression
2. anxiety
3. substance abuse
4. general medical disorders

Question 2

blockade of what dopaminergic tract results in antipsychotic effects

Answer 2

mesolimbic

Question 3

what is the major desired effect of pharmacotherapy w schizophrenia

Answer 3

avoid unwanted side effects using minimum effective dose

Question 4

list the 1st gen antipschotics

Answer 4

haloperidol
chlorpromazine
fluphenazine
loxapine
perphenazine
thioridazine
thiothixene
trifluoperazine

Question 5

first generization antipsychotics work for what symptoms

Answer 5

positive, not negative

Question 6

low potency antipsychotics have low affinity to what

Answer 6

D2 receptors

Question 7

what is the high potency antipsychotics (need low mg doses)

Answer 7

haloperidol
thiothixene
fluphenazine
trifluorperazine

Question 8

what are the extrapyramidal symptoms

Answer 8

parkinsonism
dystonia
akathisia

Question 9

what is an inability to stay still or calm

Answer 9

akathisia

Question 10

what drug helps with long term complications of antipsychotics

Answer 10

clozaril

Question 11

what is neurolepticmalignant syndrome

Answer 11

occurs with high potency drugs (haloperidol)

Question 12

what are differences in serotonin syndrome and neuroleptic malignant syndrome

Answer 12

NMS has slow onset (7 days)
NMS has incontinence
NMS has hyperthermia
NMS is more deadly

Question 13

what causes hyperprolatinemia with antipsychoitics

Answer 13

D2 blockade in tuberinfunibular (usually drugs that end in -done… risperidone)

Question 14

what antipsychotic cuses the worst qtc prolongation

Answer 14

thioridazine and ziprasidone

Question 15

what antipsychotic drug is category X with levofloxacin

Answer 15

ziprasidone

Question 16

how does dosing of haloperidol decanoate relate to PO haloperidol

Answer 16

10-20 times first dose

Question 17

why should haloperidol not be given IV

Answer 17

torsades de pointes