headache 3 Flashcards

1
Q

what is MIDAS

A

Migraine Disability Assessment Test - series of questions about headaches over the past 3 months

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2
Q

what is the predominate symptom of migraines

A

pain

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3
Q

what 6 types of drugs can be used to treat headaches

A
  1. analgesics
  2. NSAIDs
  3. ergot alkaloids
  4. serotonin agonists
  5. opiate analgesics
  6. antiemetics
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4
Q

True/ False

analgesics/ NSAIDs are site specific for migraine associated pain

A

false

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5
Q

what treatment corresponds with mild to moderate migraine disability

A

analgesics/ NSAIDs

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6
Q

what are the most commonly used NSAIDs for migraines

A

ibuprophen, naproxen, and aspirin

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7
Q

what are considered second line for migraines

A
  1. Tylenol
  2. butabital
  3. caffeine
  4. dichloalphenazone
  5. isometheptene
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8
Q

why is butabital avoided for migraine treatment

A

causes rebound headaches and leads to overuse

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9
Q

what patients should use analgesics/ NSAIDs with caution?

A
  1. ulcer disease
  2. renal disease
  3. cardiac disease
  4. hypersensitivity
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10
Q

how do ergot alkaloids work for migraines

A

5HT1 agonists that constrict intracranial blood vessels and inhibit trigeminovascular system

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11
Q

what is the predominate pathophysiology for migraines

A

vasodilation

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12
Q

what treatment corresponds with moderate to severe migraines

A

ergot alkaloids

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13
Q

what are some of the ergot alkaloids used to treat migraines

A

ergotamine tartrate

dihydroergotamine

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14
Q

when should ergot alkaloids be used

A

early in the attack when the headache is first starting

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15
Q

why is ergotamine often combined with caffeine

A
  1. enhances absorption

2. aids in analgesia

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16
Q

what is the daily dosing for ergotamine

A
rectal = 4 mg per day
oral = 6 mg per day
17
Q

what is the weekly doising for ergotamine

A

10 mg per week for both oral and rectal

18
Q

what type of ergot alkaloid is a potent arterial constrictor; having more systemic effects?

A

ergotamine

19
Q

what ergot alkaloid has less systemic effects

A

dihydroergotamine

20
Q

what ergot alkaloid does not appear to cause rebound headaches

A

dihydroergotamine

21
Q

how is dihydroergotamine administered

A

nasal and parenteral