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Therapeutics III Test 3 > depression 1 > Flashcards

depression 1 Flashcards

1
Q

what black box warning is on all anti-derpressants

A

increase risk of suicidal ideation (due to increase of energy)

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2
Q

what are the monoamines

A

serotonin
dopamine
norepinephrine

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3
Q

what are 3 forms of non-pharm therapy for depression

A
  1. psychotherapy
  2. ECT
  3. bright light therapy
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4
Q

what are the contraindications for use of SSRIs

A
  1. use of an MAOI or use of MAOI within 14 days
  2. 5 week washout for fluoxetine
  3. concurrent use with linezolid or IV methylene blue
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5
Q

why are SSRI’s first line for depression

A

safety and tolerability

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6
Q

what are some side effects of SSRI’s

A

sexual dysfunction, nausea, and vomiting

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7
Q

what SSRI’s have the largest risk for QTc prolongation risk

A
  1. citalopram
  2. escitalopram
  3. paroxetine
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8
Q

what SSRI is a pregnancy category D drug

A

paroxetine

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9
Q

list 3 CYP 2D6 inhibiting SSRI’s

A
  1. paroxetine
  2. fluoxetine
  3. sertraline
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10
Q

what is an SSRI with a major side effect of diarrhea

A

sertraline (Zoloft)

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11
Q

what SSRI is indicated primarily for OCD disorder (not MDD)

A

fluvoxamine (Luvox)

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12
Q

what should be counseled for all SSRI’s

A
  1. GI distrubances (n/v/d)
  2. CNS effects (anxiety, headache, insomnia, depression)
  3. sexual dysfunction
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13
Q

What SNRI side effect is not seen in SSRIs

A

dose dependent increase in blood pressure

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14
Q

doses of venlafaxine greater than 150 mg have what effect

A

blocks norepinephrine causing hypertension

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15
Q

True/ False:

desvenlafaxine shows no benefit over venlafaxine

A

True

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16
Q

what SNRIs are indicated for fibromyalgia

A

duloxetine

milnacipran

17
Q

why should SNRI’s not be d/c’d abruptly

A

withdrawal syndrome of flu like symptoms

18
Q

what are the indications of bupropion

A
  1. MDD (first line)
  2. social anxiety disorder
  3. smoking cessation
19
Q

what is the MOA of bupropion

A

metabolite that acts as a norepinephrine and dopamine reuptake inhibitor

20
Q

what antidepressant can not cause serotonin syndrome

A

bupropion (no effect on serotonin)

21
Q

what are the contraindications of bupropion

A
  1. history of seizures
  2. eating disorder
  3. electrolyte imbalance
22
Q

who should use caution when using bupropion

A

alcoholics, and patients with a history of mania or psychosis

23
Q

what are the adverse effects of bupropion

A
  1. seizure
  2. dry mouth
  3. constipation
  4. weight loss

Therapeutics III Test 3 (19 decks)

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