scc insitu Flashcards
mNif
Terminology: Squamous cell carcinoma in situ (SCCIS) is generic; intraepithelial neoplasia (IN) is HPV- induced SCCIS.
■ Etiology: HPVin ection, chronic low-grade balanoposthitis (poor hygiene, LS) in older individuals; chronic dermatoses (ulcerative lichen planus, lichen sclerosus).
■ Clinical ndings: Solitary, well-de ned, irregularly bordered, red patch with a glazed-to-velvety
s u r a c e o n t h e p e n i s ( F i g . 3 4 - 2 2 ) o r v u l v a ; a s s o c i a t e d d e r m a t o s e s . H P V- a s s o c i a t e d l e s i o n s a r e u s u a l l y multiocal,occurringatanysiteso theanogenitalregion(Fig.34-23).
■ Diagnosis: Lesional biopsy.
■ Course: Appearance o a nodule or ulcer suggests progression to invasive SCC (Fig. 34-24). In HPV-
associated SCCIS, rate o trans ormation to invasive SCC is relatively low; rate is higher or vulvar SCCIS:Rateo invasivenessandmetastasishigherwhenassociatedwithpoorhygiene/chronic balanoposthitis (see also Section 11).
■ Synonyms: Erythroplasia o Queyrat; Bowen disease, and bowenoid papulosis
