HPV intraepithal neoplasia Flashcards
1
Q
mNif
A
■ Etiology: HPVtypes 16, 18, 31, and 33.
■ Risk actors:Immunosuppression,occurring in HIV/AIDSdisease,iatrogenicallyinduced immunosup-
pression in solid organ transplantation.
■ Clinical ndings:Erythematouspatchesandpapules(fat-topped)(Figs.34-23and34-25);pig-
mented papules. Arrangement: Solitary, clustering, conf uence, plaque(s) ormation. Distribution:
Mucosa, anogenital and inguinocrural skin.
■ Course: Spontaneous resolution; persist or years; multiple new lesions appear; progress to invasive
SCC. Progression to invasive SCC highest in cervix, anus. Monitor cervix/anus by periodic Pap testing (cytology) to detect dysplastic changes.
