Sarcoma

Question 1

What is the margin for excision of soft tissue sarcomas?

Answer 1

1cm OR intact fascial layer

Question 2

What is the appearance of EWINGS sarcoma cells?

Answer 2

Small blue round cells

Question 3

What CD does EWINGS stain positive for characteristically?

Answer 3

CD99

Question 4

Which translocation do almost all EWINGS have?

Answer 4

11;22 (EWS/FLI1)

Other re arrangements involving ch22 can occur

Question 5

What are the poor prognostic factors for EWINGS sarcoma?

Answer 5

Age> 15
High LDH
Bone mets worse than lung/pleural
Incomplete/no surgery

Question 6

What is mgt of EWINGS localised?

Answer 6

6 cycles of VIDE then scan/biopsy and discuss at MDT to decide whether to (do surgery or radiotherapy) then 8x VAI
After surgery give adj DXT if:
-inadequate surgical margins
-

Question 7

What is VIDE chemotherapy?

Answer 7

Vincristine
Ifosfamide
Doxorubicin
Etoposide

Question 8

85% of EWINGS sarcoma have a certain translocation. What is it?

Answer 8

t(11;22)

Question 9

Sarcomas beginning with which letter have a good response to trabectedin in the second line?

Answer 9

L

Liposarcoma and leiomyosarcoma