Germ Cell Flashcards
What is the trend in the incidence of GCT?
It is increasing (120% increase since 1975)
How much does cryptorchidism increase risk of GCT?
RR 2-4 X
Which chromosomal syndrome is associated with GCT?
Klinefelter’s (47XXY)
Risk factors for GCT are (8)
Undescended testes HIV Contra lateral GCT First degree relative with GCT Infertility High dairy intake Sedentary lifestyle
Two reasons why we don’t biopsy testicular tumours
Tumour seeding
Tumour heterogeneity
What is intratubular germ cell neoplasia
Thought to begin in utero
Precedes all adult GCT apart from spermatocytic seminoma
Incidental microlithiasis on USS may indicate it
What is management of IGTN?
Patient education only
What % of GCT have a contra lateral primary?
1-2%
What IHC do virtually all seminomas exhibit?
PLAP
CKIT CD117
What is the difference in the classification of seminoma and non seminoma? (IGCCCG)
Seminoma everyone is GOOD risk
Any non pulm visc mets = INTERMEDIATE
There is NO POOR risk
A patient has a TURBT for non muscle invasive bladder cancer- name the three categories and their mgt plans
Low risk: single, 3cm Ta (non invasive)
Multiple or G2 Ta,
Recurr low risk in
How many Gy of radiotherapy for stage 2B germ cell tumour?
35 Gy
