CUP

Question 1

CK20 and CDX 2 Are positive in which malignancy?

Answer 1

Adenocarcinoma of large bowel origin

Question 2

Immunostains that indicate squamous cell carcinomas

Answer 2

CK 6, 7 and p63

Question 3

What is DD for cervical lymphadenopathy in a young man? 4 things

Answer 3

Benign causes
Lymphoma
Teratoma
Thyroid cancer

Question 4

A 20 year old has a single 2cm painless node in the left neck. FNA shows scanty lymphoid cells. What should you do next?

Answer 4

Excision biopsy

Rpt FNA won’t provide enough info. Need to show if malignancy at all!

Question 5

The only head and neck malignancy in which adjuvant Chemo is advised is..

Answer 5

Nasopharyngeal

Question 6

What is difference btw MUO and CUP?

Answer 6

MUO metastatic disease limited investigations done

CUP mets epithelial or neuroendocrine tumour with no primary after investigation and specialist review

Question 7

TTF1 positive

Answer 7

Lung

Question 8

Ck20

Answer 8

Colon

Question 9

S100, melan-a, hmb-45

Answer 9

Melanoma

Question 10

Vimentin and desmin

Answer 10

Sarcoma