Acute oncology

Question 0

Name the different mechanisms for cord compression

Answer 0

Common:-
Crush fracture
Soft tissue tumour extension

Less common:-
1-Direct extension from malig retroperitoneal or mediastinal nodes eg lymphoma
2-extra dural mass in absence of bony involvement
3- rarer intramedullary mets or primary tumour

Question 1

The five most common cancers for cord compression

Answer 1

Breast
Prostate
Lung 
Myeloma 
Lymphoma

Question 2

Which site is most common?

Cervical
Thoracic
Lumbar
Sacral

Answer 2

Thoracic

Question 3

Most common biochemical cause of AKI in tumour lysis?

Answer 3

High calcium

Used to be Uric acid but now we use prophylaxis

Question 4

In TLS when should you give calcium supplements?

Answer 4

Only when symptomatic

Question 5

Name the common chemotherapy drugs which are vesicants: 4 drugs/categories

Answer 5

Paclitaxel
Oxaliplatin
Mitomycin
Vinca alkaloids

Question 6

When should a surgical opinion be sought for extravasation?

Answer 6

Vesicant drug
Conservative management fails to improve symptoms
Tissue damage occurs

Question 7

Which chemo extravasation calls for warm compress

Answer 7

VPT

Vinca alkaloids (V-W)
Platins
Taxanes

Question 8

Which chemo extravasation calls for cold compress

Answer 8

Anthracyclines
Mitomycin

AM cold in the morning

Question 9

In hyponatremia what is the maximum in mmol/l the sodium should inc per day?

Answer 9

12

Question 10

RECIST target lesions have to be..

Answer 10

Can measure

At least one dimension is >= 1cm

Question 11

Partial response PR RECIST criteria

Answer 11

At least 30% decrease in sum of diameters of target lesions- taking as reference the baseline sum diameters

Question 12

Progressive disease in RECIST

Answer 12

> = 20% increase in sum of diameters of target lesions
Reference is the smallest sum diameter recorded since treatment started
Must also have absolute increase of 5mm OR the appearance of one or more lesions