Haem Onc

Question 1

What is in CHOP chemo?

Answer 1

Cyclo
doxo
vincristine
prednisolone

Question 2

What is duration of maintenance rituxumab for follicular lymphoma?

Answer 2

2 years

Question 3

In myeloma which tests are most important in defining prognosis as per ISS?

Answer 3

Beta 2 microglobulin

Serum albumin

Question 4

CML gene implicated in 95%

Answer 4

Abl

Question 5

Which lymphomas are CD19 and CD20 positive?

Answer 5

DLBCL

Question 6

Which lymphoma is CD30 positive?

Answer 6

Hodgkin’s disease (the classical type)

Note of interest the popcorn cells of nodular lymphocyte predominant HD expresses CD19 and 20 - like DLBCL!

Question 7

If a patient with stage 1 or 2 HD has unfavourable risk factors, how does that alter management?

Answer 7

Favourable get 2 x AVBD and 20 Gy DXT

Unfavourable 4x AVBD and 30 Gy DXT

Question 8

Two haem malignancies with EBV involved?

Answer 8

BURKITT lymphoma

Some T cell lymphomas

Question 9

A patient with advanced HODGKINS is admitted, which scoring system tells you their prognosis?
What is advanced HD anyway?

Answer 9

Advanced HD is bulky stage 2B
IPS Score has 7 items, three are patient rel, 4 are bloods 
Age >= 45
Male
Stage 4 
Hb = 15
Lymphocyte count

Question 10

In which type of lymphoma has maintenance rituximab? What is the benefit?

Answer 10

Follicular lymphoma
Increases PFS (but not OS)

Question 11

What is the issue with giving maintenance rituximab in follicular lymphoma?

Answer 11

Bronchiectasis risk, low IgG levels

Need to balance benefits and risk- Inc PFS but not OS after all

Question 12

What is the management of primary CNS lymphoma?

Answer 12

High dose MTX
Is very rare so must refer to a specialist centre
NO Role for RCHOP