Salmonella

Question 1

What does salmonellosis do?

Answer 1

Causes gastroenteritis and enteric fever, sometimes becoming bacteremia, fever, and other complications

Question 2

Typhoid fever is caused by what in humans vs research models?

Answer 2

S. typhi in humans, S. typhimurium in mice

Question 3

Once Salmonella survive the trip to the small intestine, what do they do?

Answer 3

Invade M cells

Question 4

How does the pathogen facilitate entry into M cells and survive past that point?

Answer 4

Type III secretory apparatus triggered by signal transduction and gene expression

Question 5

What is the name of the DNA region that encodes type III secretory apparatuses in Salmonella?

Answer 5

SPI1.

Question 6

What are the names of the proteins that the SPI1 type III secretory apparatus secretes to get into the M cell?

Answer 6

Sip proteins, which facilitate invasion

Question 7

What are the names of the proteins that gain the pathogen access into macrophages?

Answer 7

Export proteins (EPs)

Question 8

Short list of virulence factors controlled by two-component signaling

Answer 8

Chemotaxis in E. coli
Pertussis toxin in Bordatella pertussis
Capsule in Pseudomonas aeruginosa

Question 9

Name the 2-component signaling in Salmonella

Answer 9

PhoPQ

Question 10

What is the difference in genes required for entry into M cells and macrophages vs macrophage survival?

Answer 10

prg in entry, pag in macrophages