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Microbiology > Salivary Pellicle 2 > Flashcards

Salivary Pellicle 2 Flashcards

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1
Q

What does the enamel pellicle consist of

A 
mucins 
PRP
statherin 
amylase
lysozyme
lactoferrin 
Ig
GTFs (bacterial)
Glucans (bacterial)
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2
Q

what si the pellicle a a prerequisite

A

bacterial attachement

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3
Q

why are some mucin functions

A

tissue coating

lubrication

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4
Q

what is the tissue coating action of mcucins

A

protective hard/soft tissues
form acquired pellicle
aggregate microbes for removal
conc antimicrobial mols at interface

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5
Q

what si the lubrication function of mucin

A

alight themselves with direction of flow

increase lubricating qualities

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6
Q

what is the interaction MG1

A

attracts some sp
s.sanguinis
s.mitis
actinomyces

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7
Q

what si the interactions assc with MG2

A 
attracts MANY bac sp 
s.sanguinis
s.gordonii
E.corrodens
s.aureus
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8
Q

what are some features of MG2 and is interaction with bacteria

A

long protein core with short CHO chain often end in sialic acid
neurmidase cleaves sialic acid expo galactose (bac binding area)

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9
Q

what si the antibacterial effect of MG2

A

proteolytic cleavage of MG2 = peptides kill bac

anti fungal peptides assc

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10
Q

what si the proteolytic cleavage

A

release of peptides nerves from acidic, basic PRPs, statherin and histatns

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11
Q

what is special about proline

A

flexible

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12
Q

what are the 3 groups of PRPs

A

acidic
basic
Glycosylated

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13
Q

explain he acidic fam of PRPs

A

unique to saliva
affinity for HA
antic function

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14
Q

explain basic fam of PRPs

A

in saliva, nasal and bronchial sec

complex with tannic acid

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15
Q

what si the gycosylated fam of PRPs Imp for

A

newly formed pellicle

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16
Q

what do PRPs essentially do

A

stop uncontrollable remineralisation of both by occupy nucleation sites and holding Ca and Phos

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17
Q

give an individual who has higher levels of PRp in saliva

A

caries free

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18
Q

does caries present affect qualities of saliva

A

yes

caries free pt usually antibacterial proteins etc

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19
Q

how does the acidic fam of PRP work

A

bind to HA
conformational change
Terminus expo to receptor

eg A viscosus

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20
Q

how does the glycosylated fam of PRPs work

A

bind to HA

bind to s mutans efficiently

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21
Q

PRPs are strong promoters for what

A

bacterial adhesion

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22
Q

what are the terminals of PRPs

A

amino - control CaPhos

carboxyl - nterctaion with bac

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23
Q

what are interactions of PRPs said to be

A

highly sp

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24
Q

what do the interactions of PRPs dept on

A

proline-glutamie dipeptide

dont inhibit adhesion of bac when in solution

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25
Q

what do statherins prevent

A

primary and secondary CaPhos disposition

26
Q

what si the c terminal of statheirn involved in

A

binding to pedicle and conformational change

27
Q

what does sthatehrins aid

A

A viscous and F nucleate bind to HAp

28
Q

what are the bonds in amylase

A

alpha 1,4 glycosidic bond

29
Q

what is the function of amylase major

A

digestion starches

30
Q

what are the other features of amylase

A

essential for formation of pellicle
bacterial receptor
forme heterotypic mixed micelle like structures

31
Q

what is amylase a bac receptor for

A

s sanguines and s gorndonii

32
Q

what are glucans

A

glucose polysaccharides with glucose molesucels joined by (alpha) 1,3/1,6 links

33
Q

in formation of gluons what is the enzyme used

A

glucosyltransferase

34
Q

what re water soluble glucans

A

dextrans

(1,6) alpha

35
Q

what are water insoluble glucans

A

mutans 1,3/1,6 (alpha) links

36
Q

wha is imp about pellicle attached GTFs

A

in pellicle
immobilised enzymes active and prod sticky polysacc
binding site for bacteria adhesion

37
Q

what are Ig found in pellicle

A

IgA

IgG

38
Q

what is the most abundant Ig found in pellicle

A

IgA2

shorter hinge resist protease

39
Q

what do the pellicle attached Ig do

A

inhibit growth & adherence of some sp

antiseptic
immunise ag s.mutans

40
Q

what are cystatins

A

inhibitors of cysteine proteases

41
Q

what are cystatins linked to

A

pellicle formation and remineralisation
control of perio disease
protect salivary proteins from degardation

42
Q

what are histatins

A

histidine rich cationic (+ve) peptides

43
Q

what are the main properties of histatins

A

anti fungal - anticandidal

antibacterial - smutans

44
Q

what are histamines incorp into

A

acquired pellicle

45
Q

what are some other components of the pellicle

A

lysozyme
lactoferrin
albumin

46
Q

what is a lysozyme

A

muramidase
n - acetylmuramidase
cationic protein

47
Q

where are lysozymes present

A

in numerous organs and most body fluids

48
Q

where are the sources of oral lysozymes

A

major & minor salivary glands, phagocytic cells and gingival crevicular fluid

49
Q

what bacteria tend to be more resistant to lysosmyes and why

A

gm -ve

due to LPS in cel wal

50
Q

what do lysozyme activate

A

bacterial autolysins

‘suicide packages’

51
Q

what is lactoferrin

A

iron chelating glycoprotein

52
Q

what is the principle action of lactoferrin

A

block growth of iron dept organisms with b’static effect

  • binds to LPS
  • inhibit endotoxin activity
53
Q

what is HOSCN a product of

A

salivary peroxidase activity

54
Q

what is HOSCN

A

enzyme adsorb onto HA

55
Q

what does HOSCN do

A

block glucose uptake
inhibit amino acid trans
damage inner mem
inhibit hexokinase

56
Q

what are some antimicrobial components of saliva

A 
lactoferrin 
IgA
Mucins 
Antimicrobial peptides 
Enzymes 
Proteins
57
Q

what are th antimcirbial enzymes in saliva

A

lysozyme
glycosides
peroxidase

58
Q

what are the antimicrobial proteins in saliva

A

glycoproteins
statherins
histidine rich proteins
proline rich proteins

59
Q

what is the thickness of the pellicle before bac attach

A

1-2uM (takes an hour)

60
Q

what are the factors involved in pellicle to plaque

A 
MG1
sIgA
lysozyme
- all bind to bac cell walls 
pioneer sp (s gordonii and s sanguinis)

Microbiology (13 decks)

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