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Pathology > SALIVARY GLAND PATHOLOGY > Flashcards

SALIVARY GLAND PATHOLOGY Flashcards

1
Q

SALIVARY GLANDS
 Major
(3)

A

 Parotid
 Submandibular
 Sublingual

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2
Q

SALIVARY GLANDS
 Minor
(7)

A

 Palate
 Buccal mucosa
 Tongue
 Floor of mouth
 Labial mucosa
 Retromolar pad
 Oropharynyx

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3
Q

DISTRIBUTION OF MINOR SALIVARY GLANDS
 Palate –%
 Tongue –%
 Lips –%
 Cheeks –%
 Retromolar –%

A

60
10
10
10
10

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4
Q

Glands of Von Ebner

A

 Circumvalate papillae –
serous

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5
Q

 Glands of Blandin and Nuhn

A

 Anterior ventral – mucous

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6
Q

 Glands of Weber

A

 Posterior lateral border -
mucous

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7
Q

GLANDS OF VON EBNER
(2)

A

 Circumvalate papillae
 Serous

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8
Q

GLANDS OF WEBER
(2)

A

 Foliate papillae
 Mucous

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9
Q

GLANDS OF BLANDIN AND NUNN
(2)

A

 Anterior ventral
 Mucous

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10
Q

Mucin dissects through mylohyoid muscle, presenting as a

A

neck mass

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11
Q

HISTOLOGY
(3)

A

Pseudoepitheliomatous hyperplasia
Sialometaplasia
Coagulative necrosis of the glands

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12
Q

SJOGREN SYNDROME
(4)

A

Autoimmune disorder
Dry mouth and dry eyes
Primary vs. Secondary
Bilateral enlargement of parotid gland

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13
Q

SJOGREN SYNDROME
Bilateral enlargement of parotid gland
(2)

A

 Benign lymphoepithelial lesion (BLEL)
 Mikulicz’s disease

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14
Q

SJOGREN SYNDROME
Laboratory values
(4)

A

 Anti-SS-A
 Anti-SS-B
 RF
 ANA

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15
Q

TUMOR DISTRIBUTION:
MAJOR SALIVARY GLANDS
Parotid
 Benign
 Malignant

A

50%
50%

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16
Q

TUMOR DISTRIBUTION:
MAJOR SALIVARY GLANDS
Submandibular
 Benign
 Malignant

A

40%
60%

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17
Q

TUMOR DISTRIBUTION:
MAJOR SALIVARY GLANDS
Sublingual
 Benign
 Malignant

A

20%
80%

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18
Q

TUMOR DISTRIBUTION:
MINOR SALIVARY GLANDS
 Palate
 Benign
 Malignant

A

50%
50%

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19
Q

TUMOR DISTRIBUTION:
MINOR SALIVARY GLANDS
 Buccal Mucosa
 Benign
 Malignant

A

50%
50%

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20
Q

TUMOR DISTRIBUTION:
MINOR SALIVARY GLANDS
Upper Labial Mucosa
 Benign
 Malignant

21
Q

TUMOR DISTRIBUTION:
MINOR SALIVARY GLANDS
Lower Labial Mucosa
 Benign
 Malignant

22
Q

TUMOR DISTRIBUTION:
MINOR SALIVARY GLANDS
Tongue
 Up to –% malignant

23
Q

TUMOR DISTRIBUTION:
MINOR SALIVARY GLANDS
Floor of Mouth
 Up to –% malignant

24
Q

TUMOR DISTRIBUTION:
MINOR SALIVARY GLANDS
Retromolar pad
 Up to –% malignant

25
Q

Feature: Benign
Growth rate
Induration
Symtomatology
Ulceration

A

Slow growth
Movable
Asymptomatic
Intact mucosa

26
Q

Feature: Malignant
Growth rate
Induration
Symtomatology
Ulceration

A

Rapid growth
Fixed
Symptomatic
Ulcerated

27
Q

BENIGN SALIVARY GLAND
TUMORS
(5)

A

Benign Mixed Tumor (Pleomorphic Adenoma)
Monomorphic Adenoma
Warthin’s Tumor (Papillary Cystadenoma Lymphomatosum)
Oncocytoma
Ductal Papillomas

28
Q

PLEOMORPHIC ADENOMA
(3)

A

 Most common salivary gland neoplasm
 Middle-aged females
 Painless slowly growing mass

29
Q

PLEOMORPHIC ADENOMA
HISTOLOGY
(3)

A

Variable histology
Mixture of ductal and
myoepithelial elements
Encapsulated

30
Q

MONOMORPHIC ADENOMA
(3)

A

 Upper lip
 Middle-aged females
 Painless slowly growing mass

31
Q

MONOMORPHIC ADENOMA
HISTOLOGY
(5)

A

 Uniform pattern
 Single layered cords of columnar or cuboidal epithelium
 May demonstrate papillary projections
 Loose connective tissue stroma, with prominent vascularity
 Thin fibrous capsule

32
Q

PAPILLARY CYSTADENOMA
LYMPHOMATOSUM
(6)

A

2nd most common benign salivary gland
neoplasm
Parotid gland
Bilateral
Middle-aged males
-Lower in blacks
Smoking
Painless slowly growing nodular mass

33
Q

PAPILLARY CYSTADENOMA
LYMPHOMATOSUM
HISTOLOGY
(4)

A

 Oncocytic ductal epithelium
 Uniform double rows
 Lymphoid aggregate
 Papillary cystic configuration

34
Q

ONCOCYTOMA
(4)

A

Rare salivary gland neoplasm
Large epithelial cells, oncocytes
Females, 8th decade
Parotid
-`Painless slowly growing mass Multifocal

35
Q

ONCOCYTOMA
HISTOLOGY
(3)

A

 Large polyhedral cells abundant in granular
eosinophilic cytoplasm
- mitochondria
 Limited stroma
- Thin fibrovascular septa
 Lymphoid infiltrate

36
Q

MALIGNANT SALIVARY GLAND
TUMORS
(6)

A

 Mucoepidermoid Carcinoma
 Adenoid Cystic Carcinoma
 Polymorphous Low-Grade Adenocarcinoma
 Acinic Cell Carcinoma
 Carcinoma ex-Mixed Tumor
 Adenocarcinoma NOS

37
Q

MUCOEPIDERMOID CARCINOMA
(3)

A

 Most common malignant salivary gland
neoplasm
 Middle-aged females
 Clinically mistaken for a mucocele

38
Q

MUCOEPIDERMOID CARCINOMA
HISTOLOGY
(3)

A

 Mucous producing cells
 Epidermoid (squamous) cells
 May be cystic and / or solid

39
Q

ADENOID CYSTIC CARCINOMA
(3)

A

 Best recognized salivary gland tumor
 Middle-aged females
 Slowly growing mass, painful

40
Q

ADENOID CYSTIC CARCINOMA
HISTOLOGY
(4)

A

Myoepithelial and ductal cells
Perineural and perivascular invasion
Cribiform pattern
SWISS CHEESE

41
Q

POLYMORPHOUS LOW-GRADE
ADENOCARCINOMA
(3)

A

 Common malignant MINOR salivary gland
neoplasm
 Middle-aged females
 Favors palate

42
Q

POLYMORPHOUS LOW-GRADE
ADENOCARCINOMA
HISTOLOGY
(4)

A

 Deceptive uniform appearance
 Different growth patterns
 Perineural and perivascular invasion
 Indian filing

43
Q

ACINIC CELL CARCINOMA
(5)

A

Parotid
Serous acinar differentiation
Middle-aged females
Slow-growing
Low-grade malignancy

44
Q

ACINIC CELL CARCINOMA
HISTOLOGY
(4)

A

 Well circumscribed
 May be infiltrative
 Serous acinar cell
 Abundant granular basophilic cytoplasm and a
round, stained eccentric nucleus

45
Q

CARCINOMA EX-PLEOMORPHIC
ADENOMA
(4)

A

 Long standing pleomorphic adenoma
 Older adults
 Rapid growth
 Pain and ulceration

46
Q

CARCINOMA EX-PLEOMORPHIC
ADENOMA
HISTOLOGY
(2)

A

 Typical benign mixed tumor
 Malignant degeneration
- Cellular pleomorphism
- Abnormal mitotic activity
- Capsular invasion

47
Q

ADENOCARCINOMA NOS
(2)

A

 Uncommon salivary gland neoplasm
 Middle-aged females

48
Q

ADENOCARCINOMA NOS
HISTOLOGY
(1)

A

 Variable histology

Pathology (23 decks)

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