S52(8) Mucormycosis

Question 1

Major Mucor Risk Factors

Answer 1

Poorly controlled diabetes mellitus
A1C 14

Persistent neutropenia
Malignancy
HSCT

Question 2

Mucor Clinical Presentation

Answer 2

Tissue becomes red and inflamed -> black from necrosis

Signs of rapidly growing infection: necrotic eschars of
the nasal cavity and turbinates, facial lesions, exopytic or necrotic lesions of the hard palate

Medical emergency

Can have orbital and cerebral invasion

Question 3

Diagnostic Review Mucormycosis

Answer 3

CT
Halo sign specific to Aspergillosis
Reverse halo sign specific to Mucormycosis

Question 4

Drugs for treatment of Mucormycosis

Answer 4

Posaconazole and Isavuconazole

Question 5

Mucor Treatment

Answer 5

Surgical Debridement
MEDICAL EMERGENCY

Antifungal therapy
Lipisomal amphotericin B 5-10 mg/kg per day OR
Posaconazole 300mg once daily

Alternative: Isavuconazonium 372mg q8h x6 doses then 372mg once daily