S50(2) CMV

Question 1

CMV first line treatment?

Answer 1

gancyclovir (IV)
valcyclovir (PO)
Letermovir okay for prophylaxis

Question 2

What is CMV?

Answer 2

Double stranded DNA virus

Question 3

CMV Route of transmission:

Answer 3

direct contact with fluids (ex: blood, sex)

Question 4

CMV Primary infection:

Answer 4

infection in seronegative patients

Can be congenital exposure in babies

Question 5

CMV Secondary infection:

Answer 5

activation of a latent infection or reinfection

Question 6

If CMV patient presents with:
Pneumonia, 
Meningoencephalitis
Graft failure (transplant)
Viremia

Answer 6

Immunocompromised

Question 7

If CMV patient presents with:
Retinitis
Polyradiculopathy
Colitis

Answer 7

HIV

Question 8

If CMV patient presents with:
Thrombocytopenia/ hemolytic anemia
Mental retardation
Deafness

Answer 8

Congenital

Question 9

If CMV patient presents with:
Hepatitis
GBS
Myocarditis
Maculopapular and rubelliform rash

Answer 9

Other

Question 10

CMV Trestment
1st Line = Ganciclovir
1st Line = Valganciclovir
Prophylaxis = Letermovir

Answer 10

True

Question 11

1st line for treatment
Prodrug
IV only

Answer 11

Ganciclovir

Question 12

CBC w/ diff at baseline and twice weekly, BMP (for SCr) at baseline and at least weekly, pregnancy test

Answer 12

Ganciclovir

Question 13

1st line for treatment
Prodrug of ganciclovir
Oral only

Answer 13

Valganciclovir

Question 14

CBC w/ diff at baseline and twice weekly, BMP at baseline and at least weekly, pregnancy test

Answer 14

Valganciclovir

Question 15

For resistant CMV
IV only
Must give fluids
Electrolyte replacement

Answer 15

Foscarnet

Question 16

BMP (electrolytes and kidney) at baseline and daily while inpatient, CBC daily while inpatient, EKG, I/Os

Answer 16

Foscarnet

Question 17

For resistant CMV
IV only
Given with probenecid - DDI

Answer 17

Cidofovir

Question 18

For prophylaxis CMV only

PO

Answer 18

Letermovir