S52(7) Apergillosis Flashcards
Aspergillus
voriconazole
Aspergillus Risk Factors
Prolonged neutropenia
Hematopoietic stem cell transplant (HSCT) aka bone marrow transplant (BMT)
Solid organ transplant (SOT)
Hematologic malignancy
β-1,3-D glucan
Present in the cell wall of Candida species, Aspergillosis, PCP, and Fusariosis
True
Diagnostic Review
Halo sign specific to Aspergillosis
Galactomannan - Specific to Aspergillosis
Aspergillosis Diagnosis
Culture
Bronchiolalveolar Lavage (BAL) recommended for pulmonary infection
Usually grow in 2-5 days
Special stains
Aspergillosis Diagnosis
CT Chest recommended for pulmonary infection
Halo sign Air crescent Nodules Wedge shaped infarcts Ground glass opacity reflecting hemorrhage
Aspergillosis Diagnosis
1,3-β-D glucan is recommended in high risk populations
Aspergillus
Candidiasis
Fusariosis
PJP
Aspergillosis Diagnosis
Galactomannan recommended in certain populations
Sensitivity ~ 70%
Zosyn
Aspergillosis
Invasive pulmonary
First line: voriconazole
True