S50(1) Viruses and drugs Flashcards
Monoclonal Antibody Against Binding Receptor:
Bamlanivimab
True
Inhibition of Viral Nucleic Acid Synthesis: Acyclovir Cidofovir Foscarnet Ganciclovir Letermovir Remdesivir
True
Valacyclovir and acyclovir
Important ADR/ Monitoring:
Neurotoxicity
AKI
valacyclovir and acyclovir
Counseling Points:
Stay hydrated to prevent hurting the kidneys
Changes in mental state, confusion, hallucination should be reported to a doctor
N/V/D
Bamlanivimab – EUA only
EUA for mild to moderate COVID-19 with risk factors for progressing to severe COVID-19
Bamlanivimab
Counseling Points:
60 minute infusion
Administer within 10d of symptoms onset
Must have positive SARS-CoV-2 test
Cidofovir
Important ADR/ Monitoring:
- MUST be co-administered with probenecid
- DRUG-DRUG interactions
- MUST have pre-hydration fluids with 1 L of IV NS
- Requires monitoring of neutrophils for neutropenia
Cidofovir is contraindicated in patients with a sulfa allergy
True
Infertility and Embryotoxic concerns – both men and women need to use a back up method for 3 months when taking cidofovir
True
Foscarnet
Important ADR/ Monitoring:
- DOSING IS WEIRD!
- MUST be administered with hydrating fluids
- Electrolyte wasting: Ca, Mg, K, Phos
- Very nephrotoxic
- QTc prolongation
- Anemia and granulosytopenia
Ganciclovir and Valganciclovir
- BBW: Bone Marrow Suppression, leukopenia - CBC w/ diff at baseline and twice weekly
- BBW: teratogentic – pregnancy test
- AKI - BMP at baseline and at least weekly
Letermovir
Only indicated for CMV prophylaxis in bone marrow transplant (BMT) recipients
IV but check for drug-drug interactions first
Ribavirin
Important ADR/ Monitoring:
BBW: appropriate use, hemolytic anemia, pregnancy
LOTs of toxicities – need pre-treatment labs
Classic: flu-like symptoms, alopecia
Extremely expensive
CMV drug to use
ganciclovir
HSV drug to use
acyclovir
