Rotavirus Flashcards
What are the structural proteins of Rotavirus? What is their significance?
VP-1 through VP-6; VP4 and VP7 are outer core proteins which Ab are directed against.
What is the significance of VP6 in Rotavirus?
Its the most abundant protein; Used for diagnosis
What are some complications of Rotavirus infection?
Dehydration and Metabolic acidosis
Which patients normally contract Rotavirus? Transmission?
Children younger than 5; Fecal-oral transmission
How does Rotavirus present clinically?
- Infects proximal small intestine
- Initially: fever and emesis.
- WATERY diarrhea
- Emesis resolves in 3 days, diarrhea lasts for 8.
How does an immunodeficiency change the situation?
Symptoms and asysmptomatic shedding are prolonged.
What are some signs of Rotavirus?
Isotonic dehydration, compensated metabolic acidosis, Malabsorption
What are some conditions associated with Rotavirus?
Encephalitis, Acute Myositis
What factors will increase risk of hospitalization with Rotavirus?
Lack of breastfeeding, low birth weight, daycare attendance, Male gender
How is Rotavirus diagnosed?
- PCR works well even in late illness course.
- Latex Agglutination for first few days of illness
- Enzyme immunoassay
How can Rotavirus infection be prevented? Treated?
Vaccine, Hygiene, Breast feeding;
Rehydration
Discuss RotaTeq vaccine
Live/Oral, pentavalent vaccine, no preservatives.
Discuss Rotarix vaccine
Live/Oral, Strain G1P1A, A powder with calcium carbonate buffer, Applicator contains latex, No preservatives
When is the first dose of Rotateq or Rotarix given?
Between the ages of 6w-14w; Not given after 15w.
When is the final does of Rotateq or Rotarix given?
8 months for Rotateq; Since Rotarix is 2 doses, a 6 month dose isn’t needed.
